Inflamação Crónica

Objectives

·       Identify the main challenges that are posed today in the area of inflammation. We intended to transmit an integrated view of the main pathways and molecular mechanisms associated with inflammation and its implication in health and disease models in different systems;

·       Inflammation considered as a dynamic and relevant process in the different stages of pathophysiological processes aiming the repair/regeneration of the systems;

·       Identify the potential of the inflammatory process in the development of preventive measures and in the development of new therapeutics that, when applied, will promote healthy aging and the quality of life of the populations;

·       Stimulate the scientific investigation in this area through the formulation of scientific hypotheses, that can be tested for later critical analysis and integration of the results obtained in the current knowledge;

·       Development of feasible research plan with identification of opportunities and associated risks.

General characterization

Code

121005

Credits

3

Responsible teacher

Professor Doutor Fernando Manuel Pimentel dos Santos

Hours

Weekly - Available soon

Total - Available soon

Teaching language

Portuguese

Prerequisites

 

Bibliography

The participating teachers / researchers provide the recommended bibliography prior to the beginning of the Curricular Unit. It is recommended, that the bibliography consists of scientific articles that should form the basis of theoretical-practical classes and lectures, and should be available on the internet in appropriate databases. It will be sought in each edition of the course to provide the most recent scientific information. Students will be encouraged to share notes and information about the Curricular Unit.

Teaching method

The achievement of the objectives of the Curricular Unit is done through theoretical-practical classes and lectures, on each of the themes. The method of choice for acquiring knowledge and the development of skills and competences is thus based on the presentation of the professors own experience and on the discussion of previously selected scientific articles.

Models that involve the participation of the students and that are based on the critical discussion of the scientific articles representative of the different programmatic contents are favoured whenever possible and appropriate. Each topic should have as a corollary the placement of pertinent questions about it, favouring the development of scientific hypotheses.

Evaluation method

The evaluation will involve two components: presentation and critical discussion of a scientific paper (40%), writing a summary of a research project proposal or a thematic work (60%).

Subject matter

1. Inflammation, mechanisms and implications

- Inflammasome

- Endothelium

- Myofibroblast, fibrosis and tissue regeneration

- Macrophagic subpopulations, fibrosis and tissu e regeneration

2. Inflammation and Musculoskeletal System

- Rheumatoid arthritis and Spondylarthritis as models of inflammatory disease.

- New pathophysiological pathways with interest in diagnosis and therapy

- The image in the early diagnosis and therapeutic monitoring

3. Inflammation and Nervous System

- Inflammation and Neurodegenerative Diseases

- Inflammation and Ischemia

4. Inflammation and Eye

- Ocular inflammation and immunity

- Inflammation and repercussions in different ocular segments (conjunctiva, uvea, sclera)

5. Inflammation and Atherosclerosis

- Inflammation and immunity in the progression and therapeutics of Atherosclerosis

- Lipids and lipoproteins and Atherosclerosis

6. Inflammation and Nutrition

- Microbiota and inflammation

- Food components (e.g. fatty acids, eicosanoids, polyphenols, xenoestrogens) and inflammation

Programs

Programs where the course is taught: