Nutrition and Metabolism II

Objectives

This UC is intended that students know in depth the metabolism of the main biomolecules of the human organism and to understand the metabolism of an integrated and global manner. The role of diet on disease mechanisms. It is intended that the student is able to: (1) know the main metabolic pathways of lipids and proteins; (2) support the dietary recommendations with a metabolic knowledge; (3) understand the role of vitamins in metabolic regulation and its relationship with the metabolic disease; (4) understand the role of diet in microbiota modulation; (5) understand the role of diet in the correction of dysbiosis; (6) understand the role of diet in epigenetic regulation; and (7) interpret the metabolism in the light of chronobiology.

General characterization

Code

41006

Credits

Responsible teacher

Prof.ª Doutora Conceição Calhau

Hours

Weekly - Available soon

Total - Available soon

Teaching language

Portuguese

Prerequisites

Bibliography

Baynes JW, Dominiczak MH: Medical Biochemistry. 3rd ed. Elsevier Mosby. Nova Iorque. 2009
Berg JM, Tymoczko JL, Stryer L: Biochemistry. 7th ed. International Edition. W.H. Freeman and Company. Nova Iorque. 2012

· Brody T.: Nutritional Biochemistry. 2nd. Ed. Academic Press. San Diego. 1999.

· David H. Alpers, William F Stenson, Beth Taylor, Dennis M Bier: Manual of Nutritional Therapeutics. Lippincott, Williams & Wilkins. Fifth Ed. 2008.

· Frayn KN. Regulação metabólica. 3rd ed. U. Porto Editorial. Porto. 2012

· Murray RK, Granner DK, Mayes PA, Rodwell VW: Harper's Illustrated Biochemistry. 29th ed. McGraw-Hill Medical. Londres. 2012

· Stipanuk MH: Biochemical, Physiological & Molecular Aspects of Human Nutrition. 2nd ed. Elsevier Science. St. Louis. 2006

· Voet D et al: Fundamentals of Biochemistry: Life at the Molecular Level. 2nd edition. Wiley Publishers. New York. 2006

Teaching method

The course is organized in lectures and theorico-practical classes: 2 weekly lectures for all students with a duration of 50 min each; 1 case-study class per week of 2 h, in classes with a maximum of 15 students.

Evaluation method

The evaluation has a practical component and a final exam, both graded from 0 to 20. The assessment of the practicals is continuous, corresponds to 40% of the final grade, and takes into account the following criteria: performance and attendance of students; attitude and knowledge demonstrated by the students. The final exam is 60% of the final grade, it is a multiple choice written exam, and is covers all the theoretical and practical topics taught. The presence in the examination is conditional to attendance to at least 2/3 of the practical classes and a practical grade of at least 9.5.

Subject matter

Module 1
Protein metabolism
Purine and pyrimidine bases
Lipid metabolism
Cholesterol and bile acids; diet, cholesterol and hypertension
Metabolism Integration
The macronutrients and cell signaling molecules

Module 2
Vitamins
Micronutrients and metabolic disorders
Polyphenols and metabolic disease

Module 3
Diet and metabolism of xenobiotics
Carcinogens in the diet: food processing

Module 4
Nutrients and intrauterine ontogenesis (epigenetic regulation of gene expression)
Metabolism and appetite regulation
Microbiota
Chronobiology, metabolism and nutrition

Programs

Programs where the course is taught:

Nutrition Science Degree