General Pharmacology
Objectives
In small groups classes, attitudes and soft skills are also addressed.
Learning outcomes:
Identify molecular targets and pathways that can be manipulated by drugs
. Identify drugs that are available
. Justify the main pharmacodinamic and pharmacokinetics principles
. Apply the pharmacodinamic and pharmacokinetics principles to specific drugs/situations
. Integrate the principles of pharmacology in the process of drug evaluation (efficacy, safety and quality)
. Apply the principles of drug evaluation to specific situations: generics and biosimilars
General characterization
Code
11119
Credits
4
Responsible teacher
Prof.ª Doutora Maria Emília Monteiro
Hours
Weekly - Available soon
Total - Available soon
Teaching language
Portuguese
Prerequisites
Bibliography
BASIC & CLINICAL PHARMACOLOGY, B. G. Katzung and A.Trevor, 14th edition, McGrawHill Companies, Inc., 2017
RANG & DALE'S PHARMACOLOGY, Rang et al., 8th edition, Elsevier/Churchill Livingstone, 2015
PRINCIPLES OF PHARMACOLOGY The Pathophysiologic Basis of Drug Therapy
D. E. Golan, E.J. Amstrong, A. W. Armstrong, 4th edition, Wolters Kluwer, 2017
GOODMAN & GILMANS THE PHARMACOLOGICAL BASIS OF THERAPEUTICS.
L. L. Brunton, B. C. Knollmann, R. Hilal-Dandan, 13th Edition, McGrawHill,
2017
TERAPÊUTICA MEDICAMENTOSA E SUAS BASES FARMACOLÓGICAS
S.Guimarães, D.Moura e P.Soares da Silva, 6ª edição, Porto Editora, 2014
Artigos científicos
www.ncbi.nlm.nih.gov
http://pcs.isiknowledge.com
Classificação de receptores
http://iuphardb.org
Autoridade Nacional do Medicamento e Produtos de Saúde, I.P
www.infarmed.pt
Resumo das características dos fármacos aprovados pela agência europeia do medicamento
http://www.emea.europa.eu/htms/human/epar/eparintro.htm
Teaching method
General Pharmacology is a one semester course that has a workload of 4 ECTS with 3 contact hours /week : 2h of lectures and 1h of formative evaluation classes in small groups (n<16).
Teaching language is Portuguese but the slides content and bibliography are in English
Evaluation method
Final evaluation includes the distributed evaluation obtained in small groups teaching (30%); a written multiple choice test (70%) in Portuguese (compulsory) and an oral (optional) exam. A minimal grade of 10/20 in both exams is needed to get approval, except for foreign students where no minimal scores in the written test are required.
Subject matter
2. From drug origin to therapeutic use: the life cycle of drugs
3. General principles of pharmacokinetics
4. General principles of pharmacodynamics
5. Drugs that are proteins.
6. Generics and biossimilars
7. Pharmacology of cellular proliferation: general mechanisms
8. Pharmacology of the ionic transport
9. Local anaesthetics
10. General anaesthetics
11. Drugs that modify the cholinergic transmission
12. Drugs that modify the adrenergic transmission
13. General pharmacology of inflammation
14. General pharmacology of histamine
15. General mechanisms of drug toxicity
16. General mechanisms of drug interactions
17. Pharmacological basis of precision medicine