Pathophysiology and Therapeutic Targets II


Pathophysiology and Therapeutic Targets II curricular unit is oriented to the integration of pathophysiology, pharmacology of organs and systems (except CNS) and to the application of already acquired general concepts of pathophysiology, pharmacodynamics and pharmacokinetics.
By the end of the course the student should be able to show:

• Knowledge of the causes and mechanisms that explain the changes found in major diseases and the mechanisms of action of drugs, in a perspective that goes from the system to the molecule.
• Skills of critical thinking, applied to the interpretation of pathophysiological and pharmacological mechanisms, using the methodology of problem-based learning.
• Attitude of information research leading to, individually or in groups, to an adequate utilization of all the human and technological resources available for pathophysiology and pharmacology learning.

General characterization





Responsible teacher

Prof. Doutor Nuno Neuparth


Weekly - Available soon

Total - Available soon

Teaching language





PATHOPHYSIOLOGY; Damjanov. WB Elsevier Saunders Co, 2009
COLOR ATLAS OF PATHOPHYSIOLOGY; Silbernagl, Lang F Thieme, 2016
BASIC & CLINICAL PHARMACOLOGY, B.G.Katzung  and A. Trevor, 14th edition,
McGraw-Hill Companies, Inc., 2017
RANG & DALE'S PHARMACOLOGY, Rang et al., 8th edition, Elsevier/Churchill Livingstone, 2015
PRINCIPLES OF PHARMACOLOGY – The Pathophysiologic Basis of Drug Therapy, D. E. Golan, E.J. Amstrong, A. W. Armstrong, 4rth edition, Wolters Kluwer, 2017.
TERAPÊUTICA MEDICAMENTOSA E SUAS BASES FARMACOLÓGICAS, Serafim Guimarães, Daniel Moura et al., 6ª edição, Porto Editora, 2014
GOODMAN & GILMAN’S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, L. L. Brunton, B.C. Knollmann,R. Hilal-Dandan, 13th Edition, McGraw-Hill, 2017
Classificação de receptores:
Autoridade Nacional do Medicamento e Produtos de Saúde, I.P:
Resumo das características dos fármacos aprovados pela agência europeia do medicamento

Teaching method

Each content section consists in lectures and tutorial sessions during which pathophysiological and pharmacological mechanisms will be analyzed. During these sessions students will have access to medical records of patients designed specifically for the method of problem-based learning.

Evaluation method

The final exam consists of a written test followed by an oral exam which is mandatory for students with a final classification equal to 10,11 or 12 values. Students´ continuous assessment during the tutorial sessions contributes 50%, or 10 points, to the final grade, with the following distribution:
Average of session participation – 0 to 4
Average to presentation of learning issues topics and articles summaries-0 to 3
Presentation of syntheses and comments to syntheses – 0 to 3

Subject matter

Pathophysiology of gastro-oesophageal reflux disease and bowel disorders
Pharmacology of emesis and gastrointestinal motility
Pathophysiology of peptic ulcer disease
Pharmacology of the gastric mucosa
Pharmacology of lipoprotein metabolism
Pathophysiology and pharmacology of hemostasis
General aspects and therapeutic targets in heart and smooth muscle
Pathophysiology and Pharmacology of ischemic heart disease
Pharmacology of the renin angiotensin aldosterone system
Pharmacology of arterial hypertension and heart failure
Pharmacology of diuretics
Pathophysiology and Pharmacology of arrhythmias
Pathophysiology and pharmacology of pulmonary circulation disorders
Pharmacology of diuretics
Pharmacology of erectile dysfunction
Pathophysiology of Asthma
Pathophysiology of overlap syndrome and COPD
Pharmacology of airway inflammation, of bronchodilators and of cough
Pathophysiology of bone and joint disorders
Pharmacology of bone metabolism
Pathophysiology and pharmacology of diabetes
Pathophysiology of reproduction
Pharmacology of sexual hormones
Drug interactions


Programs where the course is taught: