Translational Medicine

Objectives

Translational Medicine is defined as scientific research that helps speed up the translation of scientific discovery into clinical practice and effective amelioration of human health and wellbeing. Thus, Translational Medicine is responsible for bridging the gap, exploring and converting, from basic research or population studies into clinical application, potentiating the available instruments of diagnosis, monitoring, and treatment of specific pathologies. By the end of the course students must have acquired knowledge and competences regarding the entire process associated with Translational Medicine.

General characterization

Code

1061014

Credits

3

Responsible teacher

Maria Paula Borges de Lemos Macedo

Hours

Weekly - Available soon

Total - Available soon

Teaching language

English

Prerequisites

 

Bibliography

• Principles of Translational Science in Medicine. From Bench to Bedside. Edited by: Martin Wehling, Ruprecht-Karls-Universität Heidelberg, Germany, 2010.

• Translational Medicine: The Future of Therapy? Edited by: James Mittra; Christopher-Paul Milne by Pan Stanford Publishing, 2013.

• Translational Medicine: Strategies and Statistics Methods. Dennis Comatos and Shein-Chung Chow (eds) 1st edition, CRC Press, 2008

• Randomized Clinical Trials: Design, Practice, and Reporting. David Machin, Peter M. Fayers; 2010, Willey-

Blackwell.

• EATRIS, a European initiative to boost translational biomedical research; Guus AMS van Dongen, Anton E Ussi3, Frank H de Man, Giovanni Migliaccio; Am J Nucl Med Mol Imaging 2013;3(2):166-174.

Teaching method

This course is based on swift theoretical introductions, designed to give context regarding the fields of knowledge to be explored, meant to be further detailed by the students themselves through the preparation and discussion. These debates are to be complemented by the students critical analysis of scientific papers in Translational Medicine.

Multidisciplinar and translational learning is to be paired with an effective mentoring approach, in which the students will be divided in 3-4 working groups, with a tutor/group, accompanied by faculty/researcher members with availability and ability to share knowledge and offer guidance. This will facilitate the development of the trainee and conversion into becoming an independent investigator.

Evaluation method

Evaluation will include a final exam (50% of the final grade), class participation of the student and the ability to argue (15%), to present and discuss scientific papers (15%), success in applying acquired knowledge to translational research (20%).

Subject matter

-Basic Discovery: the Foundation of Translational Medicine

-From the Clinic to the Bench and back to Clinic

-Designing Clinical Trials:

Regulatory affairs: Good Clinical Practices, patents.

Ethics: Watch-out cases.

Methodology: Statistical design, randomization, common tests and analysis.

Planning: Protocol, registries, authorizations, project management.

Execution: Site and patient enrollment, monitoring, data.

Closing: Reports and approval of a new drug or device.

-Academic/Industrial Partnerships in Drug Development

-Modern Biomarker Discovery: "Omics" approaches

-Tales of Translational Medicine (Study Cases)

Programs

Programs where the course is taught: