Aging and Chronic Diseases II


a) General understanding of chronic diseases in the context of infections, metabolic and neurologic degenerative diseases associated with aging.

b) Identification of physiopathological features that characterize the establishment of chronic diseases in organ systems.

c) Recognition of the main changes in the immunological and metabolic responses in chronic diseases.

d) Identify particular features of organ functioning and its relation to aging and chronic diseases.

e) Discuss the mechanisms that fail before onset and development of chronicity in different contexts (metabolic, infectious, neurodegenerative diseases).

General characterization





Responsible teacher

Margarida Correia-Neves


Weekly - Available soon

Total - Available soon

Teaching language





International journals in the areas of chronic diseases.

Teaching method

In this unit there will be:

a) Conferences on specific subjects

b) Wokshops on chapters of the program that may raise more controversy

c) Group and individual works/reports aiming to review particular areas of the subjects under discussion and the proposal of scientific hypotheses for a project in this field.

Evaluation method

The evaluation will include:

a) A synthesis work (group) to review a specific subject in this field (25% of the final grade)

b) An individual report proposing a hypothesis for a research project in this area (25% of the final grade)

c) Multiple choice test (25% of the final grade)

d) Daily evaluation (25% of the final grade).

Subject matter

a) Chronic infection: molecular and cellular mechanisms.

b) Examples of chronic infectious diseases (by Mycobacteria, such as Mycobacterium tuberculosis, Mycobacterium ulcerans e Mycobacterium avium, by viruses such as immunodeficiency vírus; cancer).

c) Normal and pathological aging: molecular and cellular mechanisms.

d) Examples of chronic diseases of the central nervous system associated with aging (Alzheimer's disease, Parkinson's disease, stroke).

e) Diseases of the metabolism: molecular and cellular mechanisms.

f) Examples of metabolic diseases associated with aging (obesity, diabetes, metabolic syndrome).


Programs where the course is taught: