Membranes in Downstream Processing


  1. To acquire general concepts about downstream processing
  2. To be able to apply previous knowledge, acquired in separation processes and transport phenomena, in the processing of biological media
  3. To be able to design process integration schemes
  4. To acquire knowledge about emerging process monitoring tools and their use for process control
  5. Understand how a specific problem may be approached by the Industry

General characterization





Responsible teacher

Isabel Maria Rola Coelhoso, João Paulo Serejo Goulão Crespo


Weekly - 4

Total - 57

Teaching language



Available soon


-        Monitoring and visualizing membrane based processes. Edited by Carme Güell, Montserrat Ferrando, Francisco López. 2009 Wiley-VCH Verlag GmbH & Co. KGaA Weinheim;

-        Microfiltration and Ultrafiltration: Principles and applications. Leos J. Zeman and Andrew L. Zydney, 1996 Marcel Dekker, Inc., New York;

-        A. Fersht, Structure and Mechanism in Protein Science,W.H. Freeman and Company, New York, 1999.

-        B. Valeur, Molecular Fluorescence. Principles and Applications, Wiley/ VCH, Germany, 2002.   

-        Marcel Mulder, Basic Principles of Membrane Technology, Kluwer Academic Press, 1996.

-        E.L. Cussler, Diffusion, second ed., Cambridge University Press, Cambridge, 1997;

Teaching method

Available soon

Evaluation method

The evaluation includes:

  1. Scientific research project and corresponding report and discussion – individual
  2. Engineering project with report and oral presentation and discussion - group of 3 students.
  3. Tests (2) - individual

The final grade is composed by 25% of the grade obtained in the research project +25% of the grade obtained in the engineering project +50% of the grade obtained in the tests (average value of the two tests).

In each component of the evaluation the grade has to be >=9.5, in a scale 0-20. 

Subject matter

  1. Introduction and general concepts
  2. Specificity of biological complex media and media /membrane interactions
  3. Product recovery and fractionation
  4. Product purification and polishing
  5. Hybrid processes and process integration
  6. Process monitoring and control


Programs where the course is taught: