Membranes in Regenerative Medicine


  1. This curricular  aims to give  the knowledge and skills which allow the student:

    -        to know the principles of Tissue Engineering, techniques for the fabrication, chemical, structural and transport characterization of tissue scaffolds while understand their importance on the different stages of cell tissue formation

    -        to know the different drug carriers using systems of controlled release, preparation methods and understand the different release mechanisms

    -        to develop and evaluate strategies for the production and optimization of tissue scaffolds and systems of controlled drug delivery

    -        to understand the development of (bio)artificial organs (artificial kidney, liver, pancreas and lungs) based on membrane processes.

    -        to know and understand the transport models inherent to each of these artificial organs and their applicability

    to be able to define strategies for the design of artificial organs with improved performance.

General characterization





Responsible teacher

Isabel Maria Rola Coelhoso, João Paulo Serejo Goulão Crespo


Weekly - 4

Total - 57

Teaching language



Available soon


W. W. Minuth, R. Strehl, K. Schumacher. Tissue Engineering, Wiley-VCH Verlag Gmbh & Co.  2005.

 W. Mark Saltzman. Tissue engineering, engineering principles for the design of replacement organs and tissues, University Press (Oxford, UK) 2004.

   Tissue engineering in Regenerative Medicine, Harold S. Bernstein Editor, Humana Press, Springer (New York, USA) 2011

 Nanobiomaterials in Drug DeliveryApplications of Nanobiomaterials Volume 9, Ed. Alexandru Grumezescu, Elsevier B.V, 2016

Specialized scientific journals

Teaching method

Available soon

Evaluation method

The evaluation includes:

  1. Scientific research project and corresponding report and discussion – individual
  2. Engineering project with report and oral presentation and discussion - group of 3 students.
  3. Tests (2) - individual

The final grade is composed by 25% of the grade obtained in the research project +25% of the grade obtained in the engineering project +50% of the grade obtained in the tests (average value of the two tests).

In each component of the evaluation the grade has to be >=9.5, in a scale 0-20. 

Subject matter

  1. Principles of Tissue Engineering and ethical issues

    -Tissue scaffolds: main requisites and characteristic, fabrication methods

    -Influence of scaffolds chemical, structural, mechanical and mass transport characteristics on the development of cell tissues(protein-scaffold interactions,mechanotransduction)

    -Types of drug carriers:characteristics, used materials, methods for production, mechanisms of delivery involved and their impact on the drug biodistribution and optimization of the different administration routes

    -Drug delivery in organs and tissues - applications in cancer, inflammation and regenerative medicine

    -Membrane processes for blood purification and detoxification – design and mass transport in hemodialyzers, bioartificial liver and main development challenges

    -Design of pancreatic systems and diffusional limitation of nutrients and cell wastes.

    -Blood oxygenators:configurations,characteristics, essential requirements and mass transport limitations in gas-liquid membrane contactors


Programs where the course is taught: