Basics of Toxicology
Objectives
- basic knowledge on pharmacokinetics, pharmacodynamics, metabolism and toxicology as well as the biological and chemical mechanisms of these phenomena.
- understand the toxic biological effects due to exposure to environmental xenobiotics, food xenobiotics or pharmacological agents.
- understand the toxicological consequences associated with inter-individual variations in biotransformation enzymes, genetic polymorphisms and genetic variation in drug metabolism .
- knowledge of practical examples of the application of these concepts in the clinics, research and industry
- skills concerning analytical methodologies applied in pharmacology and toxicology studies
- knowledge on the national, European and worldwide regulations, their differences, similarities and implications.
General characterization
Code
11184
Credits
3.0
Responsible teacher
António Sebastião Rodrigues
Hours
Weekly - 2
Total - 28
Teaching language
Português
Prerequisites
Available soon
Bibliography
Timbrell, J. A. (2008). Principles of biochemical toxicology. CRC Press.
Casarett & Doull''s Toxicology: The Basic Science of Poisons, 6th Edition, Curtis D. Klaasen, Ed.
The bibliography will also consist of recent original scientific articles in specialized journals and review articles (e.g. Annual Review of Pharmacology and Toxicology).
Teaching method
28 hours of theoretical lectures.
Evaluation will include a written examination and a group seminar (3 students) (60:40).
Evaluation method
The evaluation will comprise a final exam and a group seminar. Minimum grade will be ≥9,50 = 10
Written Exam (EE) = 60% final classification
Without consultation. Questions with multiple choice questions, assay and problem solving.
Written Exam is subject to grade improvement.
Seminar (S) = 40% final classification
Seminar (S): Presentation / discussion (15 minutes / 5 minutes) of topics for groups of 3-4 students.
Evaluation Criteria (S):
• Critical analysis
• Capacity of Synthesis
• Bibliographic search
• Time Compliance
Admission to Seminary requires:
• Reception of a presentation summary (maximum 250 words) 7 days before the date of the presentation.
The seminar is not subject to grade improvement.
The grade of the seminar can be carried over to the next year if the student has had approval ≥9,50 = 10
Subject matter
1. Brief history of toxicology. Basic principles of toxicology. The dose-response relationship. Disposition of xenobiotics.
2. Absorption, distribution and excretion of xenobiotics.
3. Toxicogenomics and toxicogenetics. Personalized Medicine.
4. Genetic toxicology. Radiobiology.
5. Toxicology of Pesticides.
6. Toxicology of Metals.
7. Risk assessment.
8. Persistent Organic Pollutants (POPS). Endocrine disrupters. Dioxins.
9. Toxicology of Metals: Cd, Hg, As.