Organic Synthesis



 It is intended that the student develops the capacity to plan strategies for the efficient synthesis of simple organic molecules, being able to compare them from an overall yield and strategic point of view.

General characterization





Responsible teacher

Paula Cristina de Sério Branco


Weekly - 4

Total - 56

Teaching language



Available soon


1. S. Warren, P. Wyatt, Organic Synthesis - The disconnection Approach. second ed., Wiley 2008.

2. J. Clayden, N. Greeves, S. Warren and P. Wothers, Organic Chemistry. Oxford University Press, 2001.

3. P. Wyatt, S. Warren, Organic Synthesis - Strategy and Control. Wiley, 2007.

4. Química Orgânica, Volume 2, Pedro Paulo Santos, IST Press, Lisboa, 2013, capítulos 15 & 17. A book of general organic chemistry well adapted to the syllabus of this course.

5. S. Prabhakar (ed.), Organic Synthetic Methodology, Edinova, Lisboa, 2000.

Teaching method

Available soon

Evaluation method

 2 TEST EACH worth 35%
LAB (PROJECT (5%) + PRATICAL EVALUATION (10%), PRACTICE REPORT (7.5%) + presentation (7.5%)) = 30%
It required a minimum score of 9.5 in the theoretical part and attendance to practical classes for approval to the discipline
 The students should perform practical work and prepare the report and do the presentation of the experimental results.

Subject matter

 Chemical synthesis objectives and practical importance.

General concepts involved in a chemical synthesis. Synthetic strategy. Linear synthesis and convergent synthesis. Synthetic yield. Economy of atoms.

Retrosynthetic analysis: general concepts of retrosynthesis. Disconnection, synthon, equivalent synthon, control synthon, functional group interconvertion, ‘umpolung’. Disconnection of one or more functional groups.

Retrosynthesis and synthesis of alicyclic compounds containing heteroatoms (N, S, O).

Methods for the obtention of compounds bearing 3- and 4-membered rings.

Brief mention to the synthesis of heterocycles.