Asymmetric Organic Chemistry I
In this course students perceive advanced methods in organic synthesis, the mechanisms that govern these transformations, based on the relationship between molecular structure versus reactivity, with a comprehensive understanding of the concepts and applications of asymmetric synthesis
Paula Cristina de Sério Branco
Weekly - 3
Total - 49
Students must have the basic knowledge in fundamental organic chemistry and its Reaction Mechanisms allowing them to an understanding and assimilation of the transmitted knowledge.
1. Organic Synthesis. Strategy and Control, P. Wyatt, S. Warren, John Wiley Sons, Lda, 2007.
2.Modern Methods of Organic Synthesis, W. Carruters and Ian Coldham, 4ª Ed., Cambridge University Press, 2004.
3. Organic Synthesis. Strategy and Control, P. Wyatt, S. Warren, John Wiley Sons, 2007.
Lectures use modern multimedia techniques. Laboratory classes are carried out in an adequately equipped laboratory. A dynamic interaction student-tutor is established.
2 TEST EACH worth 30%
SEMINAR (Group 2 elements) 15% (analysis of an article)
LAB (EVALUATION PRACTICE REPORT +) 25%
It required a minimum score of 9.5 in the theoretical part (Test + Seminar) for approval to the discipline.
1) stereoselectivity in synthesis: A review of the principles of stereochemistry. Elements of chirality. Prochiral and chiral centers. Stereoisomers. Intermediates and enantiomeric and diastereoisomeric transition state. Reactions on symmetric and asymmetric substrates. Resolution.
2) Reactive intermediates in organic chemistry: carbocations, carbanions, radicals, carbenes, nitrenes and arines. Methods of preparation and reactivity.
3)Reactivity of functional groups: reduction, oxidation and C-C bond formation using transition metal.
Stereospecific reduction of benzoin.
Quimio- and Diastereoselective reduction of benzoin acetate
Quimio- and Diastereoselective reduction of benzoin benzoate
Preparation of diazomethane
Programs where the course is taught: