Immunology

Objectives

- Acquisition of knowledge about the constitution and function of the Immune System and the mechanisms of immune response, in the different steps of the immune response.

- Learning of basic principles that relate to cells and molecules of the immune system in the defense against pathogens and how they are developed to recognize antigens.

- Acquisition of knowledge on the role of immune dysfunction in autoimmune diseases and immunodeficiencies.

- Development of skills on the applicability of methodologies / technologies used in the study of Immunology in different areas, such as, basic research and diagnosis.

- Understanding the dynamics of knowledge contained in a rapidly developing science that integrates in all other biomedical sciences.

General characterization

Code

10656

Credits

6.0

Responsible teacher

Ana Madalena Peres de Drumond Ludovice Mendes Gomes, Paula Alexandra Quintela Videira

Hours

Weekly - 4

Total - 81

Teaching language

Português

Prerequisites

Basic knowledge in Cell and Molecular Biology, Molecular Genetics, Microbiology and Biochemistry

Bibliography

- Janeway’s Immunobiology; nineth edition, Garland Science, by Kenneth Murphy and Casey Weaver

- Fundamentos de Imunologia, Lidel - Edições Técnicas,  2ª ediçao, por Fernando A. Arosa, Elsa M. Cardoso e Francisco C. Pacheco 

- Cellular and Molecular Immunology, Saunders/Elsevier, 2011 by Abbas, Lichtman, and Pillai

- Kuby Immunology; Kindt, Goldsby, Osborne

Teaching method

Teaching is mainly based in theoretical and practical lectures allowing students to acquire and apply knowledge in the field of Immunology. It is intended to attract students from the beginning to the study of immunology, foster discussion and criticism, cementing the knowledge, enable inter-relate the various issues and even with other areas of biological sciences and create foundations for the eventual implementation of Immunology their future work.

Evaluation method

The assessment of this unit is continuous. The assessment components are:

(A) theoretical assessment;

i) Consisting of mini-tests. Each mini-test has a weight of 25% each (total value of mini-tests = 50%) and include theoretical matters and each has a maximum duration of 60 minutes.

 

(B) laboratory or project assessment;

i) – Seminar /group work: weight of 25%. The themes, content and organization will be defined in the first two weeks of classes. The classification of work entails the presentation in the form of seminar and discussion.

ii) - Report: weight of 20%. Report and discussion of experiments.

iii) - Resolution of questions during the practical lectures: weight of 5%

 

(C) summative assessment;

ii) - Participation and attendance in class:

Classification attributed to final grade:

A Good - rises 1 point to note

B Enough -gets 0 points to note

C Bad-  decreases 1 value

 

Rating

Ai*50% + Bi*25% + Bii*20% + Biii*5%

Only the final grade is rounded !

 

40% of the evaluation will be held until the eighth week of the semester.

The minimum required for each component rating is 8/20.

All enrolled students must attend at least 2/3 of practical classes.

In the case of grade improvement in the exam, the grades of elements such as group work, individual work and participation during the class may remain.

In case of repetition of the discipline, the frequency of theoretical and practices lectures is valid for two years. During these two years, the student can choose to keep the score obtained prior to any of the assessment components, provided that the grades for that component were higher than 10. However, the student must always validate the grade given through a small practical test (to match the conductor), to ensure their notes.

 

Subject matter

CALENDAR OF THEORETICAL CLASSES

 

DATE

TITLE

9/09

Introduction / Overview of Immunology

16/09

Innate response

23/09

Immune response mediated by T and B cells

30/09

Antigens and antibodies

7/10

Phases of the immune response/

14/10

Cytokines and Immunotherapy I

21/10

Complement system

 28/10

Organization and expression of genes of immunoglobulins and T cell receptors

 4/11

 Major Histocompatibility Complex

11/11

Immunodeficiency, Hypersentivity & autoimmunity 

 

 

18/11

Immunohematology

25/11

Tumor Immunology  / Immunotherapy  II

2/12

Vaccines / vaccine production processes

9/ 12

 Questions

 

 

CALENDER OF PRATICAL LECTURES

NOTE: Detailed information on the practical classes, is in a separate document “Monografia das aulas práticas”

 

 

TITLE

 

Blood cells

 

Cell culture

 

Isolation of leukocytes & Leukocyte activation

 

Leukocyte  activation by analysis of nitrites

 

ELISA

 

Preparation of a protocol

 

Students  presentation

 

Precipitation reactions

 

Flow cytometry and phagocytosis

 

Antibody production

 

Immunohematology

 

 

 

SEMINARS students

 

SEMINARS students

Programs

Programs where the course is taught: