Nutrition and Metabolism II
Objectives
This UC is intended that students know in depth the metabolism of the main biomolecules of the human organism and to understand the metabolism of an integrated and global manner. The role of diet on disease mechanisms. It is intended that the student is able to: (1) know the main metabolic pathways of lipids and proteins; (2) support the dietary recommendations with a metabolic knowledge; (3) understand the role of vitamins in metabolic regulation and its relationship with the metabolic disease; (4) understand the role of diet in microbiota modulation; (5) understand the role of diet in the correction of dysbiosis; (6) understand the role of diet in epigenetic regulation; and (7) interpret the metabolism in the light of chronobiology.
General characterization
Code
41006
Credits
5
Responsible teacher
Prof.ª Doutora Ana Faria
Hours
Weekly - Available soon
Total - Available soon
Teaching language
Portuguese
Prerequisites
Bibliography
Baynes JW, Dominiczak MH: Medical Biochemistry. 3rd ed. Elsevier Mosby. Nova Iorque. 2009
Berg JM, Tymoczko JL, Stryer L: Biochemistry. 7th ed. International Edition. W.H. Freeman and Company. Nova Iorque. 2012
Brody T.: Nutritional Biochemistry. 2nd. Ed. Academic Press. San Diego. 1999.
David H. Alpers, William F Stenson, Beth Taylor, Dennis M Bier: Manual of Nutritional Therapeutics. Lippincott, Williams & Wilkins. Fifth Ed. 2008.
Frayn KN. Regulação metabólica. 3rd ed. U. Porto Editorial. Porto. 2012
Murray RK, Granner DK, Mayes PA, Rodwell VW: Harper's Illustrated Biochemistry. 31st ed. McGraw-Hill Medical. Londres. 2018
Nelson DL, Cox MM: Lehningher Principles of Biochemistry. 6th ed. W.H. Freeman and Company, Nova Iorque. 2013
Stipanuk MH: Biochemical, Physiological & Molecular Aspects of Human Nutrition. 2nd ed. Elsevier Science. St. Louis. 2006
Voet D et al: Fundamentals of Biochemistry: Life at the Molecular Level. 2nd edition. Wiley Publishers. New York. 2006
Teaching method
The course is organized in lectures and theorico-practical classes: 2 weekly lectures for all students with a duration of 50 min each; 1 practical class per week of 2 h, in classes with a maximum of 15 students.
Evaluation method
The evaluation has a practical component and a final exam, both graded from 0 to 20. The assessment of the practical component is continuous, corresponds to 40% of the final grade, and takes into account the following criteria: performance and attendance of students; attitude and knowledge demonstrated by the students. The final exam is 60% of the final grade, it is a multiple choice written exam, and it covers all the theoretical and practical topics taught. The presence in the examination is conditional to attendance to at least 2/3 of the practical classes and a practical grade of at least 9.5.
Subject matter
Module 1
Protein metabolism
Purine and pyrimidine bases
Lipid metabolism
Cholesterol and bile acids; diet, cholesterol and hypertension
Metabolism Integration
The macronutrients and cell signaling molecules
Module 2
Vitamins
Micronutrients and metabolic disorders
Module 3
Diet and metabolism of xenobiotics
Carcinogens in the diet: food processing
Module 4
Nutrients and intrauterine ontogenesis (epigenetic regulation of gene expression)
Metabolism and appetite regulation
Microbiota
Chronobiology, metabolism and nutrition