Pathophysiology and Therapeutic Targets II


The Pathophysiology and Therapeutic Targets curricular unit aims at integrating knowledge of pathophysiology and pharmacology, organized by organs and systems (except CNS) as well as the application of the general principles of pathophysiology, pharmacodynamics and pharmacokinetics already acquired.
At the end of the course the student should be able to demonstrate:
• Knowledge of the causes and mechanisms that explain the manifestations found in major diseases and the mechanisms of action of drugs, from a perspective that goes from the system to the molecule.
• Critical reasoning skills applied to the interpretation of pathophysiological and pharmacological mechanisms.
• Information search skills to make appropriate use of available resources for learning pathophysiology and pharmacology.
• Ability to work in groups, to expose their knowledge and to participate actively and appropriately in tutorial sessions.

General characterization





Responsible teacher

Prof.ª Doutora Maria Emília Monteiro


Weekly - Available soon

Total - Available soon

Teaching language





PATHOPHYSIOLOGY; Damjanov. WB Elsevier Saunders Co, 2009
COLOR ATLAS OF PATHOPHYSIOLOGY; Silbernagl, Lang F Thieme, 2016
RANG & DALE'S PHARMACOLOGY, Rang et al., 9th edition, Elsevier/Churchill Livingstone, 2019
BASIC & CLINICAL PHARMACOLOGY, B. G. Katzung and A. J. Trevor, 14th edition, McGrawHill Companies, Inc., 2018
PRINCIPLES OF PHARMACOLOGY – The Pathophysiologic Basis of Drug Therapy D. E. Golan, E. J. Armstrong, A. W. Armstrong, 4th edition,  Wolters Kluwer, 2017
GOODMAN & GILMAN’S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS. L. L. Brunton, B. C. Knollmann, R.  Hilal-Dandan, 13th Edition, McGrawHill, 2018
S.Guimarães, D.Moura e P.Soares da Silva, 6ª edição, Porto Editora, 2014

Pubmed for Scientific papers:
The International Union of Basic and Clinical Pharmacology (IUPHAR) / British Pharmacological Society (BPS) Guide to PHARMACOLOGY is an expert-curated resource of ligand-activity-target relationships, It is a portal to pharmacological information and its main aim is to provide a searchable database with quantitative information on drug targets and the prescription medicines and experimental drugs available for them.
Autoridade Nacional do Medicamento e Produtos de Saúde, I.P INFARMED
Agência europeia do medicamento European Medicines Agency

Teaching method

Teaching comprises four subject blocks (Gastrointestinal, Cardiovascular and Respiratory, Endocrine Glands and Osteoarticular System) which include lectures and tutorial sessions organized around four clinical patient processes (Gastrointestinal, Cardiovascular, Respiratory, and Endocrine Glands). with 6 sessions of 2 hours each. These tutorial sessions take place in small groups (16 students) and are guided by teachers of Pathophysiology and / or Pharmacology.

Evaluation method

Students' final evaluation includes two components with relative weights of 50%:
The distributed evaluation during the tutorial sessions that includes: participation in the sessions, presentations and discussion of individual learning needs and group presentation of the clinical cases workflow and summary.
The final exam consists of a written test (60 multi-choice questions) followed by an oral exam. The oral examination will be optional unless otherwise indicated by the chair of the curricular unit.

Subject matter

Pathophysiology and pharmacology of vomiting
Pharmacology of gastrointestinal motility
Pathophysiology of gastroesophageal reflux and gastrointestinal motility disorders
Pharmacology of the gastric mucosa. Drugs used to treat gastro-oesophageal reflux and peptic ulcer disease
Pharmacology of lipoprotein metabolism
Pathophysiology and pharmacology of Hemostasis
General aspects of therapeutic targets in the heart and smooth muscle
Pharmacology of renin-angiotensin aldosterone
Pathophysiology and pharmacology of ischemic heart disease and myocardial infarction
Pharmacology of heart failure and shock
Pharmacology of diuretics
Pharmacology of beta blockers
Pathophysiology and pharmacology of arrhythmias
Pathophysiology of pulmonary circulation disorders
Pharmacology of pulmonary hypertension and erectile dysfunction
Integrating Seminar - Hypertension
Pathophysiology of Asthma
Pathophysiology of Asthma-COPD overlap (ACO)
 Pharmacology of respiratory tract inflammation
Pharmacology of bronchodilators
Integrating Seminar - Cough
Pathophysiology of bone and joint disorders
Pharmacology of bone metabolism
Pathophysiology and pharmacology of diabetes
Pathophysiology of reproduction
Pharmacology of sex hormones


Programs where the course is taught: