Biomedicine Molecular Basis

Objectives

Doctoral program between the University of Aveiro and the University NOVA Lisboa.

 

The overall objective is to understand the multidisciplinary nature of molecular Biomedicine, integrating various areas of knowledge and relate them to medicine.

Upon completion of this advanced course the student should be able to:

• understand the fundamental principles of the disciplines represented in molecular biomedicine;

• describe the fundamental functions and molecular mechanisms at the level of the molecule, cell and organ, in relation to the human body and understand these concepts with respect to the development of disease;

• describe the application of molecular medicine in treatment strategies and in clinical practice;

• integrate the theory of molecular medicine with molecular biology procedures;

• form the molecular basis to understand and enhance the significance of the other aspects addressed within the DPBM;

• provide innovative insights and know the relevance of basic research for current problems in human health.

General characterization

Code

101259

Credits

6

Responsible teacher

Prof.ª Doutora Odete Abreu Beirão da Cruz e Silva

Hours

Weekly - Available soon

Total - Available soon

Teaching language

Portuguese or English

Prerequisites

Minimum attendance of 2/3 of the classes, without any supplementary regimen for students without attendance minimum.

Bibliography

Molecular Biology of the Cell. B. Alberts et al., (2008), 5th Edition, Garland Science Publishing. ISBN: 978-0815341116

Essential Concepts in Molecular Pathology. William Coleman and Gregory Tsongalis (2010) ELSEVIER. ISBN: 978-0-12-374418-0

Cellular and Molecular Pathobiology of Cardiovascular Disease. Monte Willis, Jonathon Homeister and James Stone (2014), Academic Press.
ISBN: 9780124052062

Fundamentals of Inflammation. Charles N. Serhan, Peter A. Ward, Derek W. Gilro (2010). Cambridge University Press.
ISBN: 978-0-521-88729-8

Protein Misfolding, Aggregation and Conformational Diseases: Part A: Protein Aggregation and Conformational Diseases. Vladimir N. Uversky and Anthony Fink (2006). Springer.
ISBN: 978-0-387-25919-2

 

Teaching method

This is an advanced course and it is expected that the students will take responsibility for their own learning. Teaching components will resort to lectures, seminars, group-based discussions.

Discussions sessions will be organized in small groups to facilitate an in-depth examination of individual topics. The discussion groups will involve faculty staff whenever possible thus justifying the number of teaching members involved. Recently published research articles, will also be brought into the discussion.

Experts on specific areas will be invited as speakers whenever possible.

The assessment will be based upon the performance of the students in the presentation of a project/scientific paper, research project and other assignments, and discussions with colleagues, and the active participation in the class.

·        Study case – presentation of a scientific article (20%);

·        Synopses of seminars– select two from the various presentations (20%);

·        Research project – presentation and discussion in a workshop format (40%);

·        Active participation in the CU – (20%).

Evaluation method

The assessment will be continuous, based upon the performance of the students in the presentations of a scientific article, research project and other assignments, and discussions with colleagues, and the active participation in the class.

Subject matter

The advanced course will focus on the molecular, cellular and physiological mechanisms of disease and will include diagnostic and therapeutic strategies.

Cellular and molecular processes in pathogenesis:

• cell injury/cell death;

• cellular adaptation.

 

Molecular and cellular basis of inflammation:

• cell types, chemical mediators;

• uncontrolled inflammation.

 

Protein aggregation and disease:

• principles of protein aggregation;

• development of amyloidogenic diseases.

 

Host pathogen interaction:

• pathogenic microorganisms/virulence;

• major groups of microorganisms responsible for human pathologies;

• infections associated with health care.

 

Examples of molecular and cellular pathogenesis in human diseases.

Focus on selected major human diseases at the molecular and cellular levels:

• cardiovascular diseases;

• cancer;

• metabolic syndromes;

• neuropathologies.

 

Principles and practice of molecular pathology:

• diagnostic approaches;

• therapeutic strategies.

Programs

Programs where the course is taught: