Active Ingredients


At the end of this course the student will have acquired the knowledge to understand the process of drug development, be able to identify the strategies involved in the design of a synthesis and know and identify the most general organic transformations

General characterization





Responsible teacher

Paula Cristina de Sério Branco


Weekly - 2

Total - 28

Teaching language



Not applicable


New Trends in Synthetic Medicinal Chemistry, F. Gualtieri, Wiley 2000.

Advanced Practical Medicinal chemistry, Ashutosh Kar, New Age International Publishers, New Delhi (2004).

Strategies For Organic Drug Synthesis And Design, Daniel Lednicer, John Wiley & Sons, Inc. (2009)

Teaching method

The curricular unit consists of a theoretical component, in which students are taught theoretical knowledge, and an individual work component, in which students analyze a work of literature which is presented orally and discussed in the classroom.

Evaluation method

The assessment consists of two written tests on the theoretical component (80%) and the analysis of a literature work provided to them on the synthesis of a compound that students should develop in a short presentation in theoretical classes (20%).

Subject matter

- Prime considerations in designing a synthesis. The retro-synthetic approach.

- New trends in synthetic medicinal chemistry.

- The chiral center. The methods for the preparation of enantiomerically pure drugs.

- Classical and bio-assisted organic synthesis

- Biocatalyzed reactions

- Combinatorial chemistry

- Peptides and peptidomimetic compounds

- Drugs based on a substituted benzene ring

- Opioid analgesics

- Five-membered heterocyclic based-drugs

- Rings that contain three or more heteroatoms


Programs where the course is taught: