Metals in Biology and Medicine

Objectives

At the end of the curricular unit the students should have acquire the following skills:

•           Acquire the main fundaments about the function of metal ions in biological systems;

•           Be able to analyze a structure and function of biomolecules containing metals;

•           Be able to discuss why the homeostasis of trace elements is essential;

•           Identify the spectroscopic techniques appropriate to investigate a metalloprotein or metal complex;

•           Develop the ability to collect and interpret scientific data;

•           Integrate and apply multidisciplinary knowledge in spectroscopy, enzyme kinetics, biochemistry, structure biology and bioinorganic;

•           Be able to work in a team;

•           Develop the ability to communicate and discuss results with specialist and non-specialists, using the appropriate scientific language;

•           Demonstrate critical spirit and show initiative;

•           Start using English as the scientific international language.

General characterization

Code

12318

Credits

6.0

Responsible teacher

Carlos Lodeiro Espino, Sofia Rocha Pauleta

Hours

Weekly - 4

Total - 56

Teaching language

Português

Prerequisites

Available soon

Bibliography

Trace Element Medicine and Chelation Therapy, RSC David M. Taylor, David, R. Williams, 1995.

Medicinal Inorganic Chemistry, J. Sessler, S. Lippard, et al. ACS Symposium Series, 2005.

Essentials in Inorganic Chemistry. For students of Pharmacy, Pharmaceutical Sciences and Medicinal Chemistry. Katja A. Stronhfeldt, Wiley, 2015.

Ligand Design in Medicinal Inorganic Chemistry, Tim Storr Editor, Wiley, 2014.

Metals in Medicine, Kames C. Dabrowiak, Inorganic Chemistry Wiley TextBook Series, Wiley, 2nd Ed. 2017.

Biological Inorganic Chemistry – Structure and reactivity. Ed. Bertini, Gray, Stiefel, Valentine. 2007. University Science Books, USA.

Metals in Medicine, J.C. Dabrowiak, 2009, Wiley.

Teaching method

Classroom teaching with theoretical classes, theoretical exercises, and seminars on clinical cases. Theoretical classes follow the defined program and are classes of voluntary attendance. Theoretical exercises and seminars are tutored classes, guided by a teacher, with compulsory attendance, designed to apply the concepts taught through the presentation and discussion of scientific articles, resolution of clinical exercises. The seminars on practical cases are presented in groups of two students (20 min of oral presentation in English, followed by 10 min of discussion).

Evaluation method

The requirements to be approved are:
1) Continuous assessment

- Mandatory attendance of 2/3 of TP classes and to all seminars.

- Participation in class: 5%;

- Classification in the seminar (2 seminar) with average of 9.5 or more; with a weighting of 25% in the final classification; classification below 9.5 in this component does not confer frequency;

- 1 Individual Mini-monography: 20% (min 10 pages, max 15, excluinding title page, index, abstract and reference list)

- 2 theoretical tests, arithmetic average with a weighting of 50% (9.5 or higher in the average of the two frequencies) (written exam).


2) Final exam
- Exam with the theoretical component, with a grade of 9.5 or higher; with a weighting of 55% in the final classification (written exam);

- Classification in the seminar (2 seminar) with average of 9.5 or more; with a weighting of 25% in the final classification;

- 1 Mini monography individual: 20% (min 10 pages, max 15, excluinding title page, index, abstract and reference list).

At any time, the written evaluation can be substituted by an oral evaluation.

Subject matter

1 – Essentials in Inorganic Chemistry

2 – Metal Centers and its Biogenesis (in Biology and Humans)

3 – Metal Ion Assimilation

4 – Metal Ion Homeostasis

5 – Biological Function of Metal Centers

6 – “Applications” of Metals Ions

7 – Environmental-derived Health Problems – Zn, Cd, Hg and others

8 – Chemotherapy using Platinum and Ruthenium Drugs.

9 – Nobel metals as therapeutic agents (Au, Ag)

10 – Metal Complexes for other diseases. Diabetes and Vanadium drugs

11 – Essentials in Chelation Therapy

Programs

Programs where the course is taught: