Asymmetric Organic Chemistry I


In this course students perceive advanced methods in organic synthesis, the mechanisms that govern these transformations, based on the relationship between molecular structure versus reactivity, with a comprehensive understanding of the concepts and applications of asymmetric synthesis

General characterization





Responsible teacher

Paula Cristina de Sério Branco


Weekly - 3

Total - 49

Teaching language



Students must have the basic knowledge in fundamental organic chemistry and its Reaction Mechanisms allowing them to an understanding and assimilation of the transmitted knowledge.


1. Organic Synthesis. Strategy and Control, P. Wyatt, S. Warren, John Wiley  Sons, Lda, 2007.


2.Modern Methods of Organic Synthesis, W. Carruters and Ian Coldham, 4ª Ed., Cambridge University Press, 2004.

 3. Organic Synthesis. Strategy and Control, P. Wyatt, S. Warren, John Wiley  Sons, 2007.

4. Workbook for Organic Synthesis, Strategy and Control, P. Wyatt, S. Warren, John Wiley Sons, 2008.


Teaching method

Lectures use modern multimedia techniques. Laboratory classes are carried out in an adequately equipped laboratory.  A dynamic interaction student-tutor is established.

Evaluation method

2 TEST EACH worth 30%
SEMINAR (Group 2 elements) 15% (analysis of an article)
It required a minimum score of 9.5 in the theoretical part (Test + Seminar)  for approval to the discipline.

Subject matter

Theoretical classes

1) stereoselectivity in synthesis: A review of the principles of stereochemistry. Elements of chirality. Prochiral and chiral centers. Stereoisomers. Intermediates and enantiomeric and diastereoisomeric transition state. Reactions on  symmetric and asymmetric substrates. Resolution.

2) Reactive intermediates in organic chemistry: carbocations, carbanions, radicals, carbenes, nitrenes and arines. Methods of preparation and reactivity.

3)Reactivity of functional groups: reduction,  oxidation and C-C bond formation using transition metal.

Pratical classes

Stereospecific reduction of benzoin.

Quimio- and Diastereoselective reduction of benzoin acetate 

Quimio- and Diastereoselective reduction of benzoin benzoate

Preparation of diazomethane





Programs where the course is taught: