Molecular Bases of Disease

Objectives

To acquire knowledge and skills about the biochemical mechanisms underlying human disease.

- To understand metabolic processes and associated pathologies.

- To be able to relate biochemical mechanisms with associated pathologies

- To acquire knowledge and skills on a seminar context and to be able to develop critical analysis, using the scientific literature.

- To be able to search and critically interpret the literature.

General characterization

Code

11179

Credits

6.0

Responsible teacher

Ligia Raquel Mendonça Faria Marques Saraiva Teixeira, Paula Alexandra Quintela Videira

Hours

Weekly - 5

Total - 70

Teaching language

Português

Prerequisites

Basic knowledge in Cell and Molecular Biology, Molecular Genetics, Microbiology and Biochemistry.

Bibliography

- Robbins Basic Pathology, 10th Edition, 2018, by Vinay Kumar, MBBS, MD, FRCPath, Abul K. Abbas, MBBS and Jon Aster, MD. ISBN: 9780323353175

-Essential Concepts in Molecular Pathology. (2010) William B. Coleman and Gregory J. Tsongalis (Eds), Academic Press.

-Molecular Basis of Health and Disease (2011) Undurti N. Das, Springer.

Teaching method

The course includes theoretical, and theoretical-practical classes. The lectures will be taught using the "data show", accompanied by complementary bibliography previously available on the website of discipline.

The theoretical-practical classes include seminars focused on specialized subjects, given by invited speakers followed by discussions with active student participation. It also includes as clinical case with questions and discussions in class.

Evaluation method

The final test on theoretical class themes - (minimum 10 values) - 70%

Case resolution -5%

Quizzes- 10% (0-20)

Seminars (seminar summary)- 15%

Classification attributed to seminars: I (0), S (10), B(15), B+ (18), MB (20)

The final grade results from the weighting of the grade of all seminars.

Delays of more than 20 minutes after the start of the seminar class will be counted as an absence.

Absences at seminars imply a zero mark.

More than 3 absences to seminars - the practical part is considered to be not done.

The final mark (seminars+ case or theoretical part) is kept for 2 years.

Subject matter

15 March Monday	Introduction and presentation of the course Basics of Pathology	Lígia Saraiva, Paula Videira Paula Videira
22-3	Infectious diseases
	*Epidemiology and Pathogenesis of Clostridium difficile infection (CDI)*	*Mónica Oleastro, abst*
29-3	Virulence factors	Lígia Saraiva
	*Sexually transmitted infections*	*Maria José Borrego, quizz*
12-4	Bacterial evasion	Jordi Zamarreno
	*Food Microbiology*	*Teresa Crespo, abst*
19-4	Antibiotic resistance	Sandra Carvalho
	*Duvidas*
26-4	Monogenic diseases. Dominant versus recessive diseases. Mutations: types and causes and examples of their pathological effects	Paula Videira
	*Cardiovascular and genetic cardiomyopathies*	*A Fernandes, quizz*
3-5	Injury and Cell Death. Apoptosis, necrosis, and cell death pathways	Margarida Braga
	*Alpha synuclein in Parkinson''s disease*	*S Tenreiro, abstr*
10-5	Inflammation and Repair. Chronic and acute inflammation.	Paula Videira
	*Carbon monoxide targeting mitochondria: modulation of apoptosis and cell metabolism*	*H Vieira, quizz*
17-5	Autoimmune and inflammatory diseases:mechanisms of disease, and examples of associated disorders and diagnostic methods. Hemodynamic disorders	Paula Videira
	*Cellular and Molecular Aspects of spondyloarthropaties*	*F Pimentel, abstract*
24-5	Liver function	Paula Videira
	*Diabetes*	*P Macedo, quizz*
31-5	Maintenance mechanisms of genetic information. Molecular Basis of cancer	Sebastião Rodrigues
	*Clinical Case , Duvidas*	*P Videira*
7-6	Biomarkers of disease and their detection	Paula Videira
14-6	Test	Paula Videira , Lígia Saraiva
To be defined	Exam	Paula Videira, Lígia Saraiva

Programs

Programs where the course is taught: