Fundamentals of Parasitic Immunology
Objectives
After this unit, students should be able to: 1. Know the constitution and the functional activity of the mammalian immune system. 2. Understanding the interactions that take place between the different elements that make up the immune system and parasites. 3. To recognize the invasion strategies, evasion and subversion of the immune system of parasitic activity. In addition, it is intended that students develop the following general skils: 4. Working methods in the laboratory. 5. Transmit and discuss scientific information or facts in a clear and accurate way.
General characterization
Code
1290003
Credits
3
Responsible teacher
Gabriela Santos-Gomes
Hours
Weekly - 3
Total - 32
Teaching language
Portuguese
Prerequisites
Not applicable
Bibliography
• Immunology. 2006. 7ª edição. Roitt I., Brostoff J., Male D. (Ed.), Mosby, London, 544 pg. • The cytokine handbook. 2008. 3ª edição. Thomson A. Academic Press, London, 1017 pg. • Advanced immunology. 1987. 2ª edição. Male D, Champion B, Cooke A, Owen M., Grower, London. • Artigos científicos disponibilizados pelos docentes.
Teaching method
Lectures. Laboratory practical classes. Project.
Evaluation method
The evaluation of learning outcomes will take into account: 1. The performance in the preparation and presentation of the project (seminar) 2. The level of success in the final examination Rating equal to or greater than 10 on a scale of 0-20 provides the approval of the present curricular unit.
Subject matter
I. Lecture contents Immune system of mammals. The complement system. Classical and alternative pathways. Models of parasites activation. Infection and inflammation. Chemokines. Leukocyte recruitment. Acquired immune response. Processing, presentation and recognition of antigens. Major histocompatibility complex. Cellular immunity. T lymphocyte. Cytokines. Humoral immunity. Antigenic selection. B. Lymphocyte specific antibody production. Orchestration of the immune response. Macrophages / lymphocytes cross talk. II. Practical contents: Morphological identification of different cell types Interpretation of dot plots of flow cytometric Chemotaxis Immunoinformatics III. Project (seminars) development