Metodologias Nucleares em Investigação



a. Distinguishing different degrees of evidence in health

b. Describe the advantages and limitations of different ty pes of clinical studies

c. To identify and discuss advantages and limitations of innovative experiment al approaches in the field of biomedicine

d. Describe the potential of the most relevant biobanks and registries at the national level


a. Choose appropriate methodologies to test hypotheses and answer specific scientific questions

b. Adjust multivariable models

c. Interpret charts and results from clinical studies and other namely OMICs based precision medicine

d. Apply the ethical principles of research with humans and animals in protocol design

e. Elaborate systematic reviews

f. Access national and international databases

g. Teamwork


a. Build and analyses databases

b. Proficiency in the use of STA TA

c. Manipulate laboratory animals an d apply for FELASA B certification

General characterization





Responsible teacher

Professora Doutora Maria Emília Carreira Saraiva Monteiro


Weekly - Available soon

Total - Available soon

Teaching language





To be defined in each specific session.

Teaching method

Teaching will be in English and will mainly include:

·       Presentation and discussion of specific clinical and biomedical research methodologies;

·       Presentation and discussion of papers and recommendations;

·       Application of recommendations and legislation to specific cases;

·       Presentation and discussion of problems;

·       Interpretation of graphs and results;

·       Presentation of biobanks and databases;

·       Presentation of OMICs based precision medicine studies;

·       Practical data analysis in Graph Prism®, Stata®, Access®;

·       Practical manipulation of experimental animals (rodents, zebrafish and insects).

Evaluation method

Assessment in the common module will be distributed over time and will include the weighting of the following components:

·       Depth and adequacy of knowledge - 40%

·       Data analysis - 20%

·       Ability to present results -20%

·       Attitudes  - 20%

Subject matter


A.  Research vs. Innovation. The health value chain. Concepts, infrastructures and funding.

B.  Science-based medicine. Degrees of evidence, types of clinical studies and stakeholders.

C.  Qualitative research: concepts and methodologies

D. Fundamentals of construction and validation of questionnaires.

E.  Advantages and disadvantages of biomedical research models and methodologies: in vitro, in vivo and in silico.

F.  The "omics" and the biomarkers: example of biomedicine / medicine interface.I.

G. Data analysis, test application and Interpretation of results (SPSS®); building databases (Access®).

H. Systematic reviews. Basic concepts in meta-analisys

SPECIFIC PART (choose 1)

A. Advanced statistics.

B. Animal Experimentation.

C. Advanced Methods in Research (laboratory)


Programs where the course is taught: