Nutrition and Metabolism I


This UC is intended that students know in depth the metabolism of the main biomolecules of the human organism and to understand the metabolism of an integrated and global manner. The role of diet on disease mechanisms. It is intended that the student is able to: (1) identify the main categories of components of the food matrix food (nutrients and non-nutrients); (2) general notions of enzymology (3) know the main metabolic pathways of carbohydrates; (4) know the role of hormones in glucose metabolism; (5) know the role of microbiota in metabolism.

General characterization





Responsible teacher

Prof.ª Doutora Conceição Calhau


Weekly - Available soon

Total - Available soon

Teaching language





• Baynes JW, Dominiczak MH: Medical Biochemistry. 3rd Ed. Elsevier Mosby. Nova Iorque. 2009
• Berg JM, Tymoczko JL, Stryer L: Biochemistry. 7th ed. International Edition. W.H. Freeman and Company. Nova Iorque. 2012
• Brody T.: Nutritional Biochemistry. 2nd. Ed. Academic Press. San Diego. 1999.
• David H. Alpers, William F Stenson, Beth Taylor, Dennis M Bier: Manual of Nutritional Therapeutics. Lippincott, Williams & Wilkins. Fifth Ed. 2008.
• Frayn KN. Regulação metabólica. 3rd Ed. U. Porto Editorial. Porto. 2012
• de Victor W. Rodwell, David Bender, Kathleen M. Botham, Peter J. Kennelly, P. Anthony Weil: Harper's Illustrated Biochemistry. 31st ed. McGraw-Hill Medical. Londres. 2018.
• Stipanuk MH: Biochemical, Physiological & Molecular Aspects of Human Nutrition. 2nd Ed. Elsevier Science. St. Louis. 2006
• Voet D et al: Fundamentals of Biochemistry: Life at the Molecular Level. 2nd Edition. Wiley Publishers. New York. 2006

Teaching method

The course is organized in lectures and theorico-practical classes: 2 weekly lectures for all students with a duration of 50 min each; 1 case-study class per week of 2 h, in classes with a maximum of 15 students.

Evaluation method

The evaluation has a practical component and a final exam, both graded from 0 to 20. The assessment of the practicals is continuous, corresponds to 40% of the final grade, and takes into account the following criteria: performance and attendance of students; attitude and knowledge demonstrated by the students. The final exam is 60% of the final grade, it is a multiple choice written exam, and is covers all the theoretical and practical topics taught. The presence in the examination is conditional to attendance to at least 2/3 of the practical classes and a practical grade of at least 9.5.

Subject matter

Module 1
Complexity of the food matrix.
Structure and biological role of macronutrients
Fluid and electrolyte balance
General notions of enzymatic activity

Module 2
Metabolic relevance of gastrointestinal motility
GI secretions
Regulation of motility and secretion at the level of the gut
Digestion and assimilation of nutrients

Module 3
Glucose metabolism
Glucose metabolism regulation: insulin and glucagon relevance


Programs where the course is taught: