Nutrition and Metabolism II


This UC is intended that students know in depth the metabolism of the main biomolecules of the human organism and to understand the metabolism of an integrated and global manner. The role of diet on disease mechanisms. It is intended that the student is able to: (1) know the main metabolic pathways of lipids, proteins and nucleic acids; (2) support the dietary recommendations with a metabolic knowledge; (3) understand the role of vitamins in metabolic regulation and its relationship with the metabolic disease; (4) understand the role of diet in microbiota modulation and in the correction of dysbiosis; (5) understand the role of diet in epigenetic regulation; and (6) interpret the metabolism in the light of chronobiology.

General characterization





Responsible teacher

Prof.ª Doutora Ana Faria


Weekly - Available soon

Total - Available soon

Teaching language





• Baynes JW, Dominiczak MH: Medical Biochemistry. 3rd ed. Elsevier Mosby. Nova Iorque. 2009
• Berg JM, Tymoczko JL, Stryer L: Biochemistry. 7th ed. International Edition. W.H. Freeman and Company. Nova Iorque. 2012
• Brody T.: Nutritional Biochemistry. 2nd. Ed. Academic Press. San Diego. 1999.
• Frayn KN. Regulação metabólica. 3rd ed. U. Porto Editorial. Porto. 2012
• Murray RK, Granner DK, Mayes PA, Rodwell VW: Harper's Illustrated Biochemistry. 31st ed. McGraw-Hill Medical. Londres. 2018
• Nelson DL, Cox MM: Lehningher Principles of Biochemistry. 6th ed. W.H. Freeman and Company, Nova Iorque. 2013
• Stipanuk MH: Biochemical, Physiological & Molecular Aspects of Human Nutrition. 2nd ed. Elsevier Science. St. Louis. 2006
• Voet D et al: Fundamentals of Biochemistry: Life at the Molecular Level. 2nd edition. Wiley Publishers. New York. 2006

Teaching method

The course is organized in lectures and theorico-practical classes: 2 weekly lectures for all students with a duration of 50 min each; 1 practical class per week of 2 h, in classes with a maximum of 15 students. In view of the exceptional situation determined by the need to adapt the pedagogical response to the contingency plans, in view of the COVID-19 pandemic crisis, the theoretical classes will be taught remotely, ensuring the security measures imposed by the FCM|NMS contingency plan.
Practical classes will assume, from the beginning, both formats, the presencial format and a distance learning modality. Practical classes will be held in the laboratory to carry out practical activity and using digital platforms when carrying out case studies.
If it is not possible to ensure the presencial classroom sessions, these will be provided to students through distance learning. In the event of this eventuality, timely information on the support to be adopted will be provided.

Evaluation method

The evaluation has a practical component and a final exam, both graded from 0 to 20. The assessment of the practical component is continuous, corresponds to 40% of the final grade, and takes into account the following criteria: performance and attendance of students; attitude and knowledge demonstrated by the students. The final exam is 60% of the final grade, it is a multiple choice written exam, and it covers all the theoretical and practical topics taught. The presence in the examination is conditional to attendance to at least 2/3 of the practical classes and a practical grade of at least 9.5.

Subject matter

Module 1
Protein metabolism
Inborn erros of aminoacid metabolism
Purine and pyrimidine bases
Lipid metabolism
Cholesterol and bile acids; diet, cholesterol and hypertension
The macronutrients and cell signaling molecules Metabolism Integration

Module 2
Micronutrients and metabolic disorders

Module 3
Nutrients and intrauterine ontogenesis (epigenetic regulation of gene expression)
Chronobiology, metabolism and nutrition
Metabolism in physical activity
Non-comunicable dchronic diseases


Programs where the course is taught: