Tissues, cells and molecules
Objectives
The UC Tissues, Cells and Molecules aims to teach in an integrated manner human molecular and cell biology, and histology. This course provides students with a fundamental knowledge that is the basis for understanding of the cellular and molecular mechanisms of disease, and also for understanding the scientific process that is the basis or modern medicine.
The overall objective of the course is materialized in the acquisition of the following theoretical knowledge and practical skills; To understand how the cells that form the human body work, how they are organized internally, and what are the functions of the molecules that constitute them; To know how cell signalling, communication and differentiation processes work; To identify and characterize different tissue types that exist in the human body and the corresponding cells and other components; To know the different organs and systems in the perspective of the different cells that make them.
General characterization
Code
11105
Credits
13
Responsible teacher
Prof. Doutor António Jacinto
Hours
Weekly - Available soon
Total - Available soon
Teaching language
Portuguese
Prerequisites
Bibliography
Biologia Molecular/Celular
Mais recomendado:
Alberts, Bruce et al.; Essential Cell Biology, 4ª ou 5ª edição, WW Norton & Company
Outros:
Alberts, Bruce et al.; Molecular Biology of the Cell; 5ª ou 6ª edição; Garland Science, Taylor & Francis group
Mais recomendado:
Alberts, Bruce et al.; Essential Cell Biology, 4ª ou 5ª edição, WW Norton & Company
Outros:
Alberts, Bruce et al.; Molecular Biology of the Cell; 5ª ou 6ª edição; Garland Science, Taylor & Francis group
Lodish, Harvey et al.; Molecular Cell Biology; 6º ou 7º Edição; W. H. Freeman and Company
Azevedo, Carlos e Sunkel, Claudio; Biologia Celular e Molecular; 5ª Edição; Lidel Edições Técnicas Lda
Quintas, Alexandre et al; Bioquímica-Organização Molecular da Vida. Lidel Edições Técnicas Lda
Histologia
Mais recomendado:
Ross, Michael H. e Pawlina, Wojcieh; Histology: A Text and Atlas, with correlated Cell and Molecular Biology, 6ª Edição; Walters Klwer/Lippincott Willliams &Wilkins
Outros:
Kierszenbaum, Abraham and Tres, Laura T. Histology and Cell Biology: An introduction to Pathology; 3º ou 4º Edição; Mosby Elsevier
Young, B and Heah J. W.; Wheaters Functional Histology, a text and colour atlas. 4ª Edição; Mosby Elsevier
Junqueira, Luiz C e Carneiro, José; Histologia Básica; 11ª ou 12ª Edição; Guanabara Kogan
Estão disponíveis na plataforma Moodle os slides das aulas bem como o material de apoio para preparação das aulas práticas.
Teaching method
The UC is organized in theoretical and practical classes. Theoretical content will be made available to students through pre-recorded classes in the form of 70 videos of 15 to 20 minutes each, which can be accessed on the Moodle platform. A theoretical review class will be held weekly, which will be transmitted online to students through a Video Conference (VC) platform, but in person assistance at the NMS facilities will also be possible if sanitary security conditions in relation to the Covid19 pandemic allow it. . Information on free online complementary content will also be made available. The set of contents to be taught corresponds to 50 hours of conventional classes.
For practical lessons, students will be organized in classes with a maximum of 16 students each. There will be 4 hours of classes per week divided into two 2-hour shifts, for a total of 24 lessons in two possible formats. In the first format, which will correspond to 10 practical lessons, each class will be divided into 2 groups (A and B) with a maximum of 8 students each, one of the groups participates in the classroom in person and the other group assists by VC. In successive classes the groups alternate in person or by VC, each group will attend 5 classes in person. The remaining 14 classes will be given in the second format in which all students participate by VC. If sanitary safety conditions regarding the Covid19 pandemic do not allow for face-to-face classes, all practical lessons will be given by VC. In the relevant content, pre-recorded videos will also be available to demonstrate practical activities.
Evaluation method
The evaluation includes the practical component and a final exam, both quantified between 0 and 20 points. Practical assessment is continuous, corresponding to 50% of the final grade, and takes into account the following assessment formats: performance and attendance of students in class; practical exercises; reports of the activities of the practical classes; attitude and knowledge demonstrated by the student; presentation of content by students; and two practical tests. The final exam is carried out on the NMS digital platforms, corresponds to 50% of the final grade, is of multiple choice and has as object all the material of the theoretical and practical classes taught. The access to the exam is conditioned by the attendance of at least 2/3 of the practical classes and the score in this exam must be at least 9.5.
Subject matter
Lectures
The content is delivered through 12 synchronous lectures, presential or VC, depending on the Covid19 sanitary security rules, 70 video recorded short lectures (15-20 mins each), and online content. This is equivalent to 50 lectures of 50 mins each in a traditional format.
Topics
Molecules: Nucleic acids, protein structure and function, lipids.
Cells: Cell Cycle, molecular and cytoplasmatic and nuclear processes.
Cell Signalling: Signalling strategies, receptors and signalling pathways.
Cell Behaviour: Apoptosis, autophagy, cell senescence, cell movement and chemotaxis, cell differentiation.
Embryology: Introduction to embryonic development.
Histology: Tissue organization, epithelia, connective tissue, bone and cartilage, muscle, blood and hematopoiesis, lymphatic system; heart and vessels, respiratory, urinary, genital tracts and endocrine system.
Seminars integrating multiple topics and exemplifying the scientific process.
Practical Classes
The content is delivered in 24 practical classes. In 10 of those sessions the class is divided in 2 groups of a maximum of 8 students each, in each session one group in present in the classroom and the other group participates via VC, in total each group attends 5 classes in person. In the remaining 14 sessions all students participate via VC. In relevant cases, video recorded content will be made available. If the Covid19 sanitary security rules do not allow presential classes, all sessions will be by VC.
Topics
Molecules: DNA extraction, protein study methods, protein electrophoresis, size exclusion chromatography, enzymatic activity. Signalling (case studies).
Cells: Organelle identification by EM, cell culture, cell cycle and signalling pathways (Case Study).
Histology: Microscopy concepts and tissue preparation techniques. Observations of epithelia, connective tissue, cartilage and bone, muscle, skin, blood lymphatic system, heart and vessels, respiratory, urinary, genital tracts and endocrine System.