Pathophysiology and Therapeutic Targets II
Objectives
The Pathophysiology and Therapeutic Targets curricular unit aims at integrating knowledge of pathophysiology and pharmacology, organized by organs and systems (except CNS) as well as the application of the general principles of pathophysiology, pharmacodynamics and pharmacokinetics already acquired.
At the end of the course the student should be able to demonstrate:
Knowledge of the causes and mechanisms that explain the manifestations found in major diseases and the mechanisms of action of drugs, from a perspective that goes from the system to the molecule.
Critical reasoning skills applied to the interpretation of pathophysiological and pharmacological mechanisms.
Information search skills to make appropriate use of available resources for learning pathophysiology and pharmacology.
Ability to work in groups, to expose their knowledge and to participate actively and appropriately in tutorial sessions.
General characterization
Code
11122
Credits
8
Responsible teacher
Prof.ª Doutora Maria Emília Monteiro
Hours
Weekly - Available soon
Total - Available soon
Teaching language
Portuguese
Prerequisites
Bibliography
Books
PATHOPHYSIOLOGY OF DISEASE; McPhee SJ. Hammer D McGraw-Hill 2019
PATHOPHYSIOLOGY; Damjanov. WB Elsevier Saunders Co, 2009
COLOR ATLAS OF PATHOPHYSIOLOGY; Silbernagl, Lang F Thieme, 2016
RANG & DALE'S PHARMACOLOGY, Rang et al., 9th edition, Elsevier/Churchill Livingstone, 2019
BASIC & CLINICAL PHARMACOLOGY, B. G. Katzung and A. J. Trevor, 14th edition, McGrawHill Companies, Inc., 2018
PRINCIPLES OF PHARMACOLOGY The Pathophysiologic Basis of Drug Therapy D. E. Golan, E. J. Armstrong, A. W. Armstrong, 4th edition, Wolters Kluwer, 2017
GOODMAN & GILMANS THE PHARMACOLOGICAL BASIS OF THERAPEUTICS. L. L. Brunton, B. C. Knollmann, R. Hilal-Dandan, 13th Edition, McGrawHill, 2018
Websites
Pubmed for Scientific papers: https://www.ncbi.nlm.nih.gov/pubmed/
The International Union of Basic and Clinical Pharmacology (IUPHAR) / British Pharmacological Society (BPS) Guide to PHARMACOLOGY is an expert-curated resource of ligand-activity-target relationships, It is a portal to pharmacological information and its main aim is to provide a searchable database with quantitative information on drug targets and the prescription medicines and experimental drugs available for them.
https://www.guidetopharmacology.org/
Autoridade Nacional do Medicamento e Produtos de Saúde, I.P INFARMED https://app10.infarmed.pt/prontuario/index.php
European Medicines Agency
https://www.ema.europa.eu/en/medicines
Teaching method
Teaching comprises five subject blocks (Gastrointestinal, Cardiovascular, Respiratory, Endocrine Glands and Osteoarticular System) which include lectures and tutorial sessions organized around clinical patient processes. These tutorial sessions (practical classes) take place in small groups (16 students) and are guided by teachers of Pathophysiology and / or Pharmacology.
Evaluation method
Students' final evaluation includes two components with relative weights of 50%:
The distributed evaluation during the tutorial sessions that includes: participation in the sessions, presentations and discussion of individual learning needs and group presentation of the clinical cases workflow and summary.
The final exam consists of a written test (60 multi-choice questions) followed by an oral exam. The oral examination will be optional unless otherwise indicated by the chair of the curricular unit.
Subject matter
Pharmacology of vomiting
Pharmacology of gastrointestinal motility
Pharmacology of inflammatory bowel disease
Pathophysiology of peptic ulcer
Pharmacology of gastric mucosa. Drugs used to treat gastro-esophageal reflux and peptic ulcer
Pharmacology of lipoprotein metabolism
Pathophysiology and pharmacology of blood coagulation
Pharmacology of renin-angiotensin aldosterone
Pharmacology of ischemic heart disease
Pharmacology of heart failure and shock
Pharmacology of diuretics
Pharmacology of cardiovascular adrenergic system: beta-blockers and alfa agonists and antagonists
Pathophysiology and pharmacology of arrhythmias
Pathophysiology of pulmonary circulation disorders
Pharmacology of pulmonary hypertension and erectile dysfunction
Pathophysiology of Asthma-COPD overlap (ACO)
Pharmacology of respiratory tract inflammation
Pharmacology of bronchodilators
Pathophysiology and pharmacology of cough
Pathophysiology of bone and joint disorders
Pharmacology of bone metabolism
Pathophysiology and pharmacology of diabetes
Pathophysiology of reproduction
Pharmacology of sex hormones
Integrating Seminar - Hypertension
Integrating Seminar Cough
Integrating Seminar- Vomiting