Molecular Alterations in Cancer


Understanding molecular mechanisms underlying carcinogenesis and cancer progression.
Initiation of the students in the practice of basic research in biomedicine.
Acquisition of theoretical knowledge and practical techniques of molecular and cytological and histological analysis.
Evaluation of data and compilation of experiences with scientific rigor.
Acquisition of skills in scientific communication.

General characterization





Responsible teacher

Prof.ª Doutora Jacinta Serpa


Weekly - Available soon

Total - Available soon

Teaching language





The bibliography will be available along the UC and students will be directed to carry out literature.

Teaching method

LECTURES-Theoretical approach to the subjects listed in the "curriculum" of CU;
PRACTICAL LECTURES- presentation of works developed by students in the UC, and
PRACTICAL CLASSES- development of experimental work, whenever possible, students will contact with professionals who are active on issues that are addressed in UC. Upon limitations on the laboratorial work, students will receive experimental data to develop the final presentation and discussion.

Evaluation method

Methods of assessment:
Development of a scientific report in an article format;
Presentation and Discussion;
Written examination.

Students with a special study status (without compulsory attendance) will be evaluated in a written examination).

For the purpose of improving UCO's grade (requested by the student), the evaluation will be carried out in the same way as the evaluation of students with special status.

The proof review process follows the guidelines of the current MIM Pedagogical Regulation.

Lectures will be presented in an e-learning methodology, which will be adopted based on the availability of recorded classes. In the event that it is not possible to conduct face-to-face classes, the practical classes will be presented in a remote system (webinar).

Subject matter

• Genetic alterations (mutations and structural DNA) and epigenetic (changes in chromatin that regulate gene expression) involved in the development and progression of cancer, giving primary emphasis to the pathophysiology and morphology of lesions.
• Signaling pathways which are predominantly altered in cancer, including WNT pathway, MAPK and PI3K.
• Cell adhesion molecules
• Extracellular matrix component
• Metabolic pathways which are predominantly altered in cancer, namely aerobic and anaerobic glycolysis and oxidative respiration, gluconeogenesis, synthesis and ß-oxidation of fatty acids and cholesterol.
• Experimental work in vitro using cell lines and molecular biology techniques
• Preparation of scientific communications, oral and paper.


Programs where the course is taught: