Nanofabrication and Characterization of Biomaterials
Objectives
The main objective of this course is to provide students with an updated description of the fabrication and characterization of nanomaterials for applications in Medicine. Key advances from recent literature will be reviewed to supplement specific lecture topics. Lab projects will be offered to students to obtain hands-on experience on nanobiomaterials processing and characterization.
At the end of this course students should be able to:
- Understand the fundamentals of different bottom-up and top-down nanofabrication techniques of biomaterials
- Understand the fundamentals of different characterization techniques of nanobiomaterials and select appropriate techniques to characterize them.
- Analyse and interpret data related to characterization of nanostructured biomaterials.
- Gain proficiency in scientific presentation skills by presenting and discussing a final work with the entire class.
General characterization
Code
12482
Credits
3.0
Responsible teacher
Pedro Miguel Cândido Barquinha
Hours
Weekly - 2
Total - 28
Teaching language
Inglês
Prerequisites
It is recommended that students have basic knowledge on materials science (e.g., different material classes) and nanotechnology (e.g., why go nano, material properties at nanoscale are different from macroscale).
Bibliography
1. Z. Cui, Nanofabrication: Principles, Capabilities and Limits, Springer (2nd edition), 2017.
2. S. Thomas, R. Thomas, A. Zachariah, R. Kumar, Spectroscopic Methods for Nanomaterials Characterization, Volume 2, Elsevier (1st edition), 2017
3. S.K. Sharma, (Ed), Handbook of Materials Characterization, Springer (1st edition), 2018
4. Chu, P.K., Liu, X., (Eds.), Biomaterials Fabrication and Processing Handbook, CRC Press, 2008.
Teaching method
TP lectures/discussion for presentation of topics and discussion of case studies.
Lab classes to obtain hands-on experience on nanobiomaterials processing and characterization techniques, as well as data analysis obtained from the multiple characterization techniques.
Continuous assessment involves 2 mini-quiz (individual) about fabrication and characterization techniques (40 %), questionnaires on lab classes (30 %) and presentation of a final work including critical review on scientific articles (30 %)
Final exam may substitute individual mini quizzes
Evaluation method
Continuous assessment involves 2 mini-quiz (individual) about fabrication and characterization techniques (40 %), questionnaires on lab classes (30 %) and presentation of a final work including critical review on scientific articles (30 %)
Final exam may substitute individual mini quizzes
"Frequencia" requires average >=9.5/20 in the lab questionnaires.
Final aproval requires "frequencia" and average of mini-quiz or exam >=9.5/20
Subject matter
Lectures
- Introduction to nanomaterials, nanofabrication and nanocharacterization
- Nanofabrication using bottom-up techniques: self-assembly and guided-self assembly, atomic layer deposition, nanostructure growth by vapor and solution -based methods, alignment of nanostructures
- Nanofabrication using top-down techniques: overview on optical, electron and ion beam lithography. Nanofabrication by replication (nanoimprint lithography). Surface modification by laser.
- Characterization part I: ionizing radiation (XPS, AES, RBS, SIMS, XRD)
- Characterization part II: microscopy (Confocal, SEM, (S)TEM and AFM)
- Characterization part III: spectroscopies (Raman, FTIR, UV-VIS-NIR, EIS)
Lab classes:
- Synthesis of gold nanoparticles
- Fabrication of graphene eletrodes by laser
- Analysis of electrodes and gold nanoparticles by SEM-EDS, XPS, AFM and Raman
- Electrochemical impedance in electrodes and their functionalization to act as glucose sensor.