The main learning objective is directed towards the awareness of the effect of scale on the interaction between biomolecules, cells and tissues and biomaterials at the nanoscale.
Specific objectives: It is intended to stimulate the student''s critical interest in characterizing nanoscale phenomena that mediate the relationship between biomolecules in the body, interaction with cells and tissue response, and their relationship with molecular biomedicine, research tools and models, and possible application in therapeutic and diagnostic platforms (drug delivery, formulations, molecular actuators), regeneration and precision medicine.
Pedro Miguel Ribeiro Viana Baptista
Weekly - 2
Total - 26
Nanomedicine (Seifalian A., Mel A., and Kalaskar D. M. Ed.), One Central Press (OCP), UK;
Dee, K.C., Puleo, D.A., Bizios, R. (eds). An Introduction to Tissue‐Biomaterial Interactions: Tissue‐Biomaterial, Wiley‐Liss, Inc., New Jersey, USA (2002)
Ratner, B.D., Hoffman, A.S., Schoen, F.J., Lemons, J.E. (eds.): Biomaterials Science: An Introduction to Materials in Medicine. Elsevier Academic Press, New York, USA (2004)
Lanza, R., Langer, R., Vacanti, J.P. (eds.) Principles of Tissue Engineering. Elsevier Academic Press, New York, USA (2007)
TP lectures/discussion for presentation of topics and discussion of case studies. Paper presentation and discussion (team work). Oral presentation of particular theme.
Assessment: Presentation and discussion of selected papers (60%); Assay on labwork with subsequent oral discussion (40%).
1. Biomolecules-biomaterials interactions
2. Tissue structures and cell processes
Integrins and adhesion proteins
Unit cell processes comprising the healing response
ECM - Structure and function
3. Cell interactions
Cell uptake, trafficking
Nanobiomaterials and organs
4. Cell/tissue models - Tissues on chip/Organ On chip
5. Methods for studying cell-bionanomaterials interaction
6. In vivo and clinical case studies
Absorption, distribution, metabolism, and excretion– nanoscale effects
Drug delivery – nanoparticles (organic, inorganic, etc)
7. Tissue response to implants; biocompatibility
Programs where the course is taught: