Medical Imaging and Theranostics
Objectives
Acquire knowledge and competences in the field of medical imaging, particularly in the basic principles of the different techniques. Understanding how the physical properties of the nanoparticles allow them to be used as contrast agents to improve the resolution of the images produced by the various techniques. Understanding how nanostructures allow the development of theranostics systems through the combination of imaging and treatment features in the same device.
General characterization
Code
12488
Credits
6.0
Responsible teacher
Paula Isabel Pereira Soares, Ricardo Nuno Pereira Verga e Afonso Vigário
Hours
Weekly - 4
Total - 56
Teaching language
Português
Prerequisites
Available soon
Bibliography
An Introduction to the Principles of Medical Imaging; Chris Guy and Dominic Ffytche; Imperial College Press – London, 2005
Medical Physics: Imaging; Jean Pope; Heinmann Educational Publishers – Oxford, 1999
Design and applications of nanoparticles in biomedical imaging, J.W.M. Bulte, M.M.J. Modo, (2016) doi:10.1007/978-3-319-42169-8.
J. Leary, J. Key, Nanoparticles for multimodal in vivo imaging in nanomedicine, Int. J. Nanomedicine. 9 (2014) 711–726. doi:10.2147/IJN.S53717.
E. Boisselier, D. Astruc, Gold nanoparticles in nanomedicine: Preparations, imaging, diagnostics, therapies and toxicity, Chem. Soc. Rev. 38 (2009) 1759–1782. doi:10.1039/b806051g.
Teaching method
The lectures will be supported by powerpoint slides. The objectives of each lesson and reading support are explained on the slides.
The practical classes will be conducted in the laboratory, where students perform exploratory experimental activities of the topics covered in the lectures.
Evaluation method
The evaluation will be divided in 3 elements:
- One theoretical test (individual) (T)
- Presentation and discussion (group) of topics related to the theoretical component (Ap);
- Report of practical lab classes (group) (Rel).
The frequency to the course is given by the presence in all lab classes and the respective evaluation (report).
Final grade will be obtained by the weighted average of all the above cited elements:
T*.55 + Ap*.35 + Rel*.1
Each element of evaluation is rounded to the first decimal. To pass, students must have, at least 9.5 in each element of evaluation.
Subject matter
Medical imaging techniques:
- X-ray and computed tomography (CT)
- Ultrasound (US)
- Positron emission tomography (PET)
- Single photon emission computed tomography (SPECT)
- Magnetic resonance imaging (MRI)
- Magnetic particle imaging (MPI)
- Fluorescence (R-X, UV-VIS, NIR)
Theranostics
- Nanostructures as new agents for diagnostics and treatment
- Gold nanoparticles for medical imaging and theranostics
- Superparamagnetic nanoparticles in theranostics: MRI, magnetic hyperthermia, and controlled drug release.