Molecular Bases of Disease
Objectives
To acquire knowledge and skills about the biochemical mechanisms underlying human disease.
- To understand metabolic processes and associated pathologies.
- To be able to relate biochemical mechanisms with associated pathologies
- To acquire knowledge and skills on a seminar context and to be able to develop critical analysis, using the scientific literature.
- To be able to search and critically interpret the literature.
General characterization
Code
11179
Credits
6.0
Responsible teacher
Ligia Raquel Mendonça Faria Marques Saraiva Teixeira, Paula Alexandra Quintela Videira
Hours
Weekly - 5
Total - 70
Teaching language
Português
Prerequisites
Basic knowledge in Cell and Molecular Biology, Molecular Genetics, Microbiology and Biochemistry.
Bibliography
- Robbins Basic Pathology, 10th Edition, 2018, by Vinay Kumar, MBBS, MD, FRCPath, Abul K. Abbas, MBBS and Jon Aster, MD. ISBN: 9780323353175
-Essential Concepts in Molecular Pathology. (2010) William B. Coleman and Gregory J. Tsongalis (Eds), Academic Press.
-Molecular Basis of Health and Disease (2011) Undurti N. Das, Springer.
Teaching method
The course includes theoretical, and theoretical-practical classes. The lectures will be taught using the "data show", accompanied by complementary bibliography previously available on the website of discipline.
The theoretical-practical classes include seminars focused on specialized subjects, given by invited speakers followed by discussions with active student participation. It also includes as clinical case with questions and discussions in class.
Evaluation method
The final test on theoretical class themes - (minimum 10 values) - 70%
Case resolution -5%
Quizzes- 10% (0-20)
Seminars (seminar summary)- 15%
Classification attributed to seminars: I (0), S (10), B(15), B+ (18), MB (20)
The final grade results from the weighting of the grade of all seminars.
Delays of more than 20 minutes after the start of the seminar class will be counted as an absence.
Absences at seminars imply a zero mark.
More than 3 absences to seminars - the practical part is considered to be not done.
The final mark (seminars+ case or theoretical part) is kept for 2 years.
Subject matter
|
Monday 7-3 |
Introduction and presentation of the course Basics of Pathology |
|
14-3 |
Infectious diseases |
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Epidemiology and Pathogenesis of Clostridium difficile infection (CDI) |
|
21-3 |
Virulence factors |
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Sexually transmitted infections |
|
28-3 |
Bacterial evasion |
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Food Microbiology |
|
4-4 |
Antibiotic resistance |
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|
Revision - questions |
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11-4
|
Monogenic diseases. Dominant versus recessive diseases. Mutations: types and causes and examples of their pathological effects |
|
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Cardiovascular and genetic cardiomyopathies |
|
2-5 |
Injury and Cell Death. Apoptosis, necrosis, and cell death pathways |
|
|
Alpha synuclein in Parkinson''s disease |
|
9-5 |
Inflammation and Repair. Chronic and acute inflammation. |
|
|
Test 1 |
|
16-5
|
Autoimmune and inflammatory diseases:mechanisms of disease, and examples of associated disorders and diagnostic methods. Hemodynamic disorders |
|
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Carbon monoxide targeting mitochondria: modulation of apoptosis and cell metabolism |
|
23-5 |
Liver function |
|
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Cellular and Molecular Aspects of spondyloarthropaties |
|
30-5 |
Maintenance mechanisms of genetic information. Molecular b sis of cancer |
|
|
Diabetes |
|
6-6 |
Biomarkers of disease and their detection |
|
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Revision Questions |
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13-6 |
Test 2 (04/6 a 21/6) |
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? |
Exame recurso (27/6 a 12/7) |
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? |
Exame Epoca especial (25/7 a 30/7) |
Programs
Programs where the course is taught: