Molecular Bases of Disease

Objectives

To acquire knowledge and skills about the biochemical mechanisms underlying human disease.

-       To understand metabolic processes and associated pathologies.

-       To be able to relate biochemical mechanisms with associated pathologies

-       To acquire knowledge and skills on a seminar context and to be able to develop critical analysis, using the scientific literature.

-      To be able to search and critically interpret the literature.

General characterization

Code

11179

Credits

6.0

Responsible teacher

Ligia Raquel Mendonça Faria Marques Saraiva Teixeira

Hours

Weekly - 5

Total - 70

Teaching language

Português

Prerequisites

Basic knowledge in Cell and Molecular Biology, Molecular Genetics, Microbiology and Biochemistry.

Bibliography

- Robbins Basic Pathology, 10th Edition, 2018, by Vinay Kumar, MBBS, MD, FRCPath, Abul K. Abbas, MBBS and Jon Aster, MD. ISBN: 9780323353175

 

 -Essential Concepts in Molecular Pathology. (2010) William B. Coleman and Gregory J. Tsongalis (Eds), Academic Press.

-Molecular Basis of Health and Disease (2011) Undurti N. Das, Springer.

Teaching method

The course includes theoretical, and theoretical-practical classes. The lectures will be taught using the "data show", accompanied by complementary bibliography previously available on the website of discipline.

The theoretical-practical classes include seminars focused on specialized subjects, given by invited speakers followed by discussions with active student participation. It also includes as clinical case with questions and discussions in class.

 

Evaluation method

The final test on theoretical class themes - (minimum 10 values) - 70%

Case resolution -5%

Quizzes- 10% (0-20)

Seminars (seminar summary)- 15%

Classification attributed to seminars: I (0), S (10), B(15), B+ (18), MB (20)

The final grade results from the weighting of the grade of all seminars.

 Delays of more than 20 minutes after the start of the seminar class will be counted as an absence.

Absences at seminars imply a zero mark.

More than 3 absences to seminars - the practical part is considered to be not done.

The final mark (seminars+ case or theoretical part) is kept for 2 years.

Subject matter

15 March

Monday

Introduction and presentation of the course

Basics of Pathology

Lígia Saraiva, Paula Videira

Paula Videira                      

22-3

Infectious diseases

 

 

Epidemiology and Pathogenesis of Clostridium difficile infection (CDI)

Mónica Oleastro, abst

29-3

Virulence factors

Lígia Saraiva

 

Sexually transmitted infections

Maria José Borrego, quizz

12-4

Bacterial evasion

Jordi Zamarreno

 

Food Microbiology                                                     

Teresa Crespo, abst

19-4

Antibiotic resistance

Sandra Carvalho

 

Duvidas

 

26-4

 

Monogenic diseases. Dominant versus recessive diseases. Mutations: types and causes and examples of their pathological effects

Paula Videira

 

Cardiovascular and genetic cardiomyopathies

A Fernandes, quizz

3-5

Injury and Cell Death. Apoptosis, necrosis, and cell death pathways

Margarida Braga

 

Alpha synuclein in Parkinson''''s disease

S Tenreiro, abstr

10-5

Inflammation and Repair.

Chronic and acute inflammation.

Paula Videira

 

Carbon monoxide targeting mitochondria: modulation of apoptosis and cell metabolism

H Vieira, quizz

17-5

 

Autoimmune and inflammatory diseases:mechanisms of disease, and examples of associated disorders and diagnostic methods. Hemodynamic disorders

Paula Videira

 

Cellular and Molecular Aspects of spondyloarthropaties

F Pimentel, subject for test june 14)

24-5

Liver function

Paula Videira

 

Diabetes

P Macedo, subject for test june 14)

31-5

Maintenance mechanisms of genetic information. Molecular Basis of cancer

Sebastião Rodrigues

 

Clinical Case , Duvidas

P Videira

7-6

Biomarkers of disease and their detection

Paula Videira

14-6

Test

Paula Videira , Lígia Saraiva

To be defined

Exam

Paula Videira, Lígia Saraiva

Programs

Programs where the course is taught: