Basics of Toxicology

Objectives

- basic knowledge on pharmacokinetics, pharmacodynamics, metabolism and toxicology as well as the biological and chemical mechanisms of these phenomena.

- understand the toxic biological effects due to exposure to environmental xenobiotics, food xenobiotics or pharmacological agents.

- understand the toxicological consequences associated with inter-individual variations in biotransformation enzymes, genetic polymorphisms and genetic variation in drug metabolism .

- knowledge of practical examples of the application of these concepts in the clinics, research and industry

- skills concerning analytical methodologies applied in pharmacology and toxicology studies

- knowledge on the national, European and worldwide regulations, their differences, similarities and implications.

General characterization

Code

11184

Credits

3.0

Responsible teacher

António Sebastião Rodrigues

Hours

Weekly - 2

Total - Available soon

Teaching language

Português

Prerequisites

Available soon

Bibliography

Timbrell, J. A. (2008). Principles of biochemical toxicology. CRC Press.
Casarett & Doull''''s Toxicology: The Basic Science of Poisons, 6th Edition, Curtis D. Klaasen, Ed.
A bibliografia consistirá também de artigos originais em revistas especializadas e artigos de revisão (e.g. Annual Review of Pharmacology and Toxicology).

Teaching method

Available soon

Evaluation method

Available soon

Subject matter

1. Brief history of toxicology. Basic principles of toxicology. The dose-response relationship. Disposition of xenobiotics.
2. Absorption, distribution and excretion of xenobiotics.
3. Toxicogenomics and toxicogenetics. Personalized Medicine.
4. Genetic toxicology. Radiobiology.
5. Toxicology of Pesticides.
6. Toxicology of Metals.
7. Risk assessment.
8. Persistent Organic Pollutants (POPS). Endocrine disrupters. Dioxins.
9. Toxicology of Metals: Cd, Hg, As.

Programs

Programs where the course is taught: