Bioinorganic Chemistry


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General characterization





Responsible teacher

Carlos Lodeiro Espino, Maria dos Anjos Lopes de Macedo


Weekly - 4

Total - 70

Teaching language



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Robert Crichton “Biological Inorganic Chemistry: An Introduction”, 2007, 1ª edição, Elsevier Science

Ana M. V. Cavaleiro “Química Inorgânica Básica”, 2004, 3ª edição, Universidade de Aveiro

Raymond Chang and Kenneth A. Goldsby, “Chemistry”, 2012, McGraw-Hill, N.Y., 11ª edição 

Patricia C. Wilkins, Ralph G. Wilkins “Inorganic Chemistry in Biology”, Oxford Chemistry Primers, 2002, 2ª edição, Oxford University Press

 J. J. R. Fraústo da Silva, R. J. P. Williams “The biological chemistry of the elements: the inorganic chemistry of life”, 2001, 2ª edição, Oxford University Press

J.J.R. Fraústo da Silva, José A.L. Silva “Os Elementos Químicos e a Vida”, 2011, 1ª Edição, Instituto Superior Técnico

José J. G. Moura, Nuno Palma “Introdução à química da vida: caderno de adequação ao ensino à distância”, 1995, 1ª edição, Universidade Aberta

Teaching method

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Evaluation method

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Subject matter

  • Introduction to Bioinorganic Chemistry
  • Chemical Reactions stoichiometry
  • Nomenclature and isomerism in coordination complexes
  • Chemical bonding in coordination compounds (HSAB theory)
  • Reactivity in coordination compound; Substitution reaction; Inert and labile compounds; Reactions mechanisms
  • Complexation equilibria; parcial and global stability constants; effect of pH and presence of other ligands
  • Magnetism and color in coordination compounds; Cristal field Theory
  • Oxidation-reduction reactions: Galvanic cell; Balance of redox equilibria; Nernst equation; effect of pH and complex formation; Latimer and Frost diagrams and its application to biological systems
  • Metal centers of proteins and enzymes; role of metal ions in biological systems.


Programs where the course is taught: