Organic Synthesis

Objectives

 

 It is intended that the student develops the capacity to plan strategies for the efficient synthesis of simple organic molecules, being able to compare them from an overall yield and strategic point of view.

General characterization

Code

10704

Credits

6.0

Responsible teacher

Luísa Maria da Silva Pinto Ferreira

Hours

Weekly - 4

Total - 56

Teaching language

Português

Prerequisites

Available soon

Bibliography

1. S. Warren, P. Wyatt, Organic Synthesis - The disconnection Approach. second ed., Wiley 2008.

2. J. Clayden, N. Greeves, S. Warren and P. Wothers, Organic Chemistry. Oxford University Press, 2001.

3. P. Wyatt, S. Warren, Organic Synthesis - Strategy and Control. Wiley, 2007.

4. Química Orgânica, Volume 2, Pedro Paulo Santos, IST Press, Lisboa, 2013, capítulos 15 & 17. A book of general organic chemistry well adapted to the syllabus of this course.

5. S. Prabhakar (ed.), Organic Synthetic Methodology, Edinova, Lisboa, 2000.

Teaching method

Available soon

Evaluation method

THEORETICAL-PRACTICAL COMPONENT 

2 TEST EACH worth 35%

PRACTICAL COMPONENT

PRACTICAL CLASSES (10% PLANNING) + PRACTICAL EXECUTION (10%) + POSTER AND PRESENTATION OF RESULTS (10%) = 30%

A minimum score of 9.5 is required in the theoretical-practical component and in the practical component

Subject matter

 Chemical synthesis objectives and practical importance.

General concepts involved in a chemical synthesis. Synthetic strategy. Linear synthesis and convergent synthesis. Synthetic yield. Economy of atoms.

Retrosynthetic analysis: general concepts of retrosynthesis. Disconnection, synthon, equivalent synthon, control synthon, functional group interconvertion, ‘umpolung’. Disconnection of one or more functional groups.

Retrosynthesis and synthesis of alicyclic compounds containing heteroatoms (N, S, O).

Methods for the obtention of compounds bearing 3- and 4-membered rings.

Brief mention to the synthesis of heterocycles.