Environmental Biochemistry

Objectives

This discipline is directed to students who wish to initiate studies in Environmental Biochemistry through various approaches and concepts based on existing knowledge of biochemistry, cell biology and toxicology. In this discipline it is intended that students acquire the fundamentals of environmental biochemistry, including the f biochemical processes in the biosphere, environmental toxicology, the effects of toxic substances in organisms, metabolism of toxic substances, among others. But also to deepen some more recent information particularly in the area of human and environmental toxicology. Students must obtain knowledge on toxicokinetics and toxicodynamics of xenobiotics. Thy must understand the main approaches and experimental design in environmental biochemistry studies. The toxicity mechanisms will be discussed as well as the processes of absorption, distribution and excretion. Emphasis will be given to the toxicokinetic and toxicodynamic of xenobiotics and to biotransformation processes and ecotoxicology. Students will be familiar with the concepto of toxicological risks. Case studies on the various applications will be used to explain the general and specific concepts of environmental biochemistry. Through seminars prepared and presented by students, it is intended that students deepen specific parts of the course. The course will allow students to develop work in diverse areas related with environmental biochemistry.

General characterization

Code

10719

Credits

3.0

Responsible teacher

Mário Emanuel Campos de Sousa Diniz

Hours

Weekly - 2

Total - 29

Teaching language

Português

Prerequisites

Available soon

Bibliography

Casarett and Doull´s Toxicology, The Basic Science of Poisons, Sixt Edition. Int. Ed, McGraw-Hill, NY 2001.

Hodgson, Ernest. A textbook of modern toxicology / Ernest Hodgson.—4th ed. 2010. Published by John Wiley & Sons, Inc., Hoboken, New Jersey

Manham SE. Toxicological chemistry and biochemistry / by Stanley E. Manahan.-- 3rd ed. CRC- Lewish Press, Boca raton, Florida. 2003

Environmental Biochemistry, Volume 3. Neelima Rajvaidya, Dilip Kumar Markandey. APH Publishing, 2005, 435pp.

Environmental Chemistry: Fundamentals. Springer Science & Business Media, 2007, 334 pp.

Environmental Biochemistry. Sanju Kumari, Random Pub., 2012, 304pp.

Teaching method

Available soon

Evaluation method

Available soon

Subject matter

I. EnvironmentalBiochemistry
1. Introduction toenvironmentalbiochemistry
1.1.Relationship between biochemistryandthe environment
1.2.Biochemistry andenvironmentalchemistry
1.3.EnvironmentalBiochemistry andbiology

IIBiochemical Processesin the Biosphere
2.1.biogeochemical cycles
2.2.Interrelationships betweenbiogeochemical cycles
2.3.The pollutantsin the biosphere
2.3.1.Conceptof pollutants andtoxic substances
2.3.2Effects of pollutantsin the biosphere:biodegradabilitytoxicity andrisk
2.3.3Risk assessmentin HumanHealth
2.3.4Ecotoxicology

IIIBiochemical processesand metabolism
3.Metabolismof toxic substances
3.1.Mechanisms(oxidationhydrolysis, reductionandconjugation)
3.2.Influence ofenzyme action
3.3.Thelevel of DNAdamage
3.4.Toxicology andeffects ofwater, soil and atmospheric pollutantsin organisms

IVBiochemistry andToxicity
4.1.Exposure to toxic substances
4.2.Routes of entryandactionin living organisms
4.3.Absorption, distribution and excretion
4.4.Biotransformationof toxic substances

Programs

Programs where the course is taught: