The role of Microbiome in Health and Disease


- Understanding the relationship of the microbiome with health and disease;

- To know the role of the intestinal microbiota for the physiological balance;

- To know the role of the microbioma in the different infections (genito-urinary, cutaneous, respiratory, rheumatologic);

- Understanding the role of the microbiome in diabetes and transplantation;

- To know the methodologies of analysis of the microbioma.

General characterization





Responsible teacher

Prof. Doutor Paulo Paixão


Weekly - Available soon

Total - Available soon

Teaching language





Andersen SB, Shapiro BJ, Vandenbroucke-Grauls C, de Vos MGJ. Microbial evolutionary medicine: from theory to clinical practice. Lancet Infect Dis. 2019 Apr 30. pii: S1473-3099(19)30045-3. doi: 10.1016/S1473-3099(19)30045-3.

Vázquez-Baeza Y, Callewaert C, Debelius J, Hyde E, Marotz C, Morton JT, Swafford A, Vrbanac A3, Dorrestein PC. Knight R Impacts of the Human Gut Microbiome on Therapeutics. Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:253-270. doi: 10.1146/annurev-pharmtox-042017-031849

Noecker C, McNally CP, Eng A, Borenstein E High-resolution characterization of the human microbiome. Transl Res. 2017 Jan;179:7-23. doi: 10.1016/j.trsl.2016.07.012.

Ranjan R, Rani A, Metwally A, McGee HS, Perkins DL. Analysis of the microbiome: Advantages of whole genome shotgun versus 16S amplicon sequencing. Biochem Biophys Res Commun. 2016 Jan 22;469(4):967-77. doi: 10.1016/j.bbrc.2015.12.083.

Teaching method

Theoretical classes will be taught by the teachers of the course via Zoom, depending on their respective specializations. The form of lecture, in which they will address issues considered essential by providing data to guide students to individual study.

Evaluation method

Student assessment – Final written examination with a multiple choice test of 20 questions (duration 30 minutes) 50% (Face-to-face).

Oral presentation and discussion of topics by groups of two students. Topics are distributed at the beginning of the course and the presentation of each theme has a duration of 20 minutes 50%.

Subject matter

- Introduction to the microbiome and its relationship with health and disease;

- The contribution of the microbiome to the physiological balance;

- The importance of the microbiome in some of the major human infections;

- General concepts of real-time PCR and specific application to the study of the microbiome;

- Principle and importance of the metagenomic analysis in the identification and characterization of the human microbiome.


Programs where the course is taught: