Biomaterials and Nanomedicine

Objectives

Specific goals: to develop critical thinking and reasoning on nanoscale events and their impact on medical aplications, such as (but not limited to) diagnostics, research in biomedicine (tools adn novel approaches), therapeutics (drug delivery, nanoformulations, molecular actuators), tissue regeneration and precision medicine.

General characterization

Code

12481

Credits

3.0

Responsible teacher

Paula Isabel Pereira Soares, Pedro Miguel Ribeiro Viana Baptista

Hours

Weekly - 3

Total - 44

Teaching language

Português

Prerequisites

Available soon

Bibliography

Bibliografia principal:
1.    Handbook of Nanoparticles (M. Aliofkhazraei Ed.), Springer. ISBN 978-3-319-15337-7;
2.    Nanomedicine (Seifalian A., Mel A., and Kalaskar D. M. Ed.), One Central Press (OCP), UK;
3.    Nano-Oncologicals: New targeting and delivery approaches, Advances in Delivery Science and Technology (M.J. Alonso and M. Garcia-Fuentes Ed), Springer; Controlled Release Society – Springer- ISBN: 978-3-319-08084-0.

Teaching method

TP lectures/discussion for presentation of topics and discussion of case studies. Focused Seminars given by invited scientists. Paper presentation and discussion (team work). Oral presentation of particular theme.

Assessment: Presentation and discussion of selected papers.; Assay on selected theme with subsequent oral presentation and discussion.

Evaluation method

Presentation and discussion of selected papers.; monography on selected theme with subsequent oral presentation and discussion.

Subject matter

Syllabus:
1.    Nanotechnology and biologic systems
a.    Scale effects and properties of nanomateriais
b.    Characterization of nanomaterials in a biology context
c.    Nanosystem-cell/nanosystems-organism interaction
d.    Pharmacology of nanodrugs
2.    Nanoparticles in biomedicine
a.    Metal NPs, polymers, lipidic, VLPs
b.    Nanovectors for drug delivery/gene therapy
c.    Controlled release mechanisms in nanodrugs
d.    Imaging via nanoplatforms
e.    Nanodiagnostics
3.    Multifunctional NPs for therapeutics
a.    Molecular Targeting
b.    EPR
c.    Multimodal: PTT, PAT, PDT, etc and applications thereof
d.    Nanoteheranostics
4.    DNA nanotechnology– self assembly and origami
5.    Lab-on-chip/organ-on-chip
6.    Nanotoxicology in humans