Asymmetric Organic Chemistry I
Objectives
In this course students perceive advanced methods in organic synthesis, the mechanisms that govern these transformations, based on the relationship between molecular structure versus reactivity, with a comprehensive understanding of the concepts and applications of asymmetric synthesis
General characterization
Code
7208
Credits
6.0
Responsible teacher
Paula Cristina de Sério Branco
Hours
Weekly - 3
Total - 49
Teaching language
Português
Prerequisites
Students must have the basic knowledge in fundamental organic chemistry and its Reaction Mechanisms allowing them to an understanding and assimilation of the transmitted knowledge.
Bibliography
1. Organic Synthesis. Strategy and Control, P. Wyatt, S. Warren, John Wiley Sons, Lda, 2007.
2.Modern Methods of Organic Synthesis, W. Carruters and Ian Coldham, 4ª Ed., Cambridge University Press, 2004.
3. Organic Synthesis. Strategy and Control, P. Wyatt, S. Warren, John Wiley Sons, 2007.
Teaching method
Lectures use modern multimedia techniques. Laboratory classes are carried out in an adequately equipped laboratory. A dynamic interaction student-tutor is established.
Evaluation method
2 TEST EACH worth 30%
SEMINAR (Group 2 elements) 15% (analysis of an article)
LAB (EVALUATION PRACTICE REPORT +) 25%
It required a minimum score of 9.5 in the theoretical part (Test + Seminar) for approval to the discipline.
Subject matter
Theoretical classes
1) stereoselectivity in synthesis: A review of the principles of stereochemistry. Elements of chirality. Prochiral and chiral centers. Stereoisomers. Intermediates and enantiomeric and diastereoisomeric transition state. Reactions on symmetric and asymmetric substrates. Resolution.
2) Reactive intermediates in organic chemistry: carbocations, carbanions, radicals, carbenes, nitrenes and arines. Methods of preparation and reactivity.
3)Reactivity of functional groups: reduction, oxidation and C-C bond formation using transition metal.
Pratical classes
Stereospecific reduction of benzoin.
Quimio- and Diastereoselective reduction of benzoin acetate
Quimio- and Diastereoselective reduction of benzoin benzoate
Preparation of diazomethane