Basics of Toxicology


- basic knowledge on pharmacokinetics, pharmacodynamics, metabolism and toxicology as well as the biological and chemical mechanisms of these phenomena.

- understand the toxic biological effects due to exposure to environmental xenobiotics, food xenobiotics or pharmacological agents.

- understand the toxicological consequences associated with inter-individual variations in biotransformation enzymes, genetic polymorphisms and genetic variation in drug metabolism .

- knowledge of practical examples of the application of these concepts in the clinics, research and industry

- skills concerning analytical methodologies applied in pharmacology and toxicology studies

- knowledge on the national, European and worldwide regulations, their differences, similarities and implications.

General characterization





Responsible teacher

António Sebastião Rodrigues


Weekly - 2

Total - 28

Teaching language



Not applicable


Timbrell, J. A. (2008). Principles of biochemical toxicology. CRC Press.
Casarett & Doull''''''''s Toxicology: The Basic Science of Poisons, 6th Edition, Curtis D. Klaasen, Ed.
A bibliografia consistirá também de artigos originais em revistas especializadas e artigos de revisão (e.g. Annual Review of Pharmacology and Toxicology).

Teaching method

28 hours of theoretical lectures.
Evaluation will include a written examination and a group seminar (maximum of 3 students) (60:40).


Evaluation method

The evaluation will comprise a final exam and a group seminar. Minimum grade will be ≥9,50 = 10

Written Exam (EE) = 60% final classification
Without consultation. Questions with multiple choice questions.
Written Exam is subject to grade improvement.

Seminar (S) = 40% final classification
Seminar (S): Presentation / discussion (15 minutes / 5 minutes) of topics for groups of up to 3 students.

Evaluation Criteria (S):
• Critical analysis
• Capacity of Synthesis
• Bibliographic search
• Time Compliance

Admission to Seminary requires:
• Reception of a presentation summary (maximum 250 words) 7 days before the date of the presentation.

The seminar is not subject to grade improvement.
The grade of the seminar can be carried over to the next year if the student has had approval ≥9,50 = 10

Subject matter

1. Brief history of toxicology. Basic principles of toxicology. The dose-response relationship. Disposition of xenobiotics.
2. Absorption, distribution and excretion of xenobiotics.
3. Toxicogenomics and toxicogenetics. Personalized Medicine.
4. Radiobiology.
5. Toxicology of Pesticides.
6. Toxicology of Metals.
7. Risk assessment.


Programs where the course is taught: