Aging and age-related diseases: From molecular mechanisms to therapies
Objectives
It is sought that for each concrete objective there is a context of investigation so that the students understand the present challenges associated with each specific objective.
All the teaching objectives will be framed in a research context, so that the students will recognize the current challenges associated with each specific objective. These objectives include:
- Identify and explain the physiological changes during aging and their contribution to age-associated chronic diseases associated with aging;
- Compare sex-dependent differences in aging;
- List the main diseases associated with aging;
- Identify and explain the main changes in cell and changes in organ and systems in aging and their contribution to the associated chronic diseases;
- Explain the general principles of the pathophysiology of cardio-metabolic diseases;
- Justify the influence of nutrition, environmental factors and genetic factors on aging and associated cardio- metabolic diseases;
- Compare biomedical research models for the discovery of new therapeutic targets in HTA, dyslipidemia, DM2;
- Identify and describe the general principles of pharmacotherapy and advanced therapies and the particularities of pharmacology in the elderly patient;
- Describe new therapeutic targets in research on hypertension, dyslipidemia, DM2 and exemplify emerging therapies.
General characterization
Code
1091011
Credits
5
Responsible teacher
Prof.ª Doutora Sílvia Vilares Conde
Hours
Weekly - Available soon
Total - Available soon
Teaching language
English
Prerequisites
Bibliography
Teaching method
This course is based on seminars, designed to provide suitable background information in the topics (from contents) to be further explored by the students led discussions. These debates might be complemented by the students critical analysis of scientific papers on topics presented in seminars.
This learning process is to be paired with an effective tutorial approach, in which the students individually or in working groups, with a tutor, accompanied by faculty/researcher available to share knowledge and offer guidance.
Evaluation will include a final project (50% of the final grade), class participation of the student and the ability to argue (20%), to present and discuss on selected topics (20%), success in applying acquired knowledge to pharmacological principles (10%).
Evaluation method
A avaliação final é baseada num projeto, a valer 50% da nota final, sendo o restante obtido através da avaliação da participação do aluno e da sua capacidade de discussão (20%), apresentação e discussão de temas (20%) e capacidade de aplicação dos conhecimentos adquiridos nos conceitos gerais de farmacoterapia (10%).| Evaluation will include a final project (50% of the final grade), class participation of the student and the ability to argue (20%), to present and discuss on selected topics (20%), success in applying acquired knowledge to pharmacological principles (10%).
Subject matter
- General Principles of Aging;
- Chronic Diseases associated with aging;
- Cellular, organ & system changes in aging and chronic diseases;
- Interpretative Theories of Aging;
- Impact of nutrition, environmental and genetic factors on aging;
- Impact of nutrition, environmental and genetic factors on aging-related chronic diseases;
- General concepts of pathophysiology of cardiometabolic diseases associated with aging; Biomedical Models for research in new therapeutic targets in cardio-metabolic disease;
- General Principles of Pharmacotherapy and Advanced therapies;
- Pharmacology in the elderly patient;
- Emerging therapies in age-related diseases.