Drug Delivery Systems
Objectives
The primary objectives of the course are:
- to make students knowledgeable about the design, formulation and evaluation of drug and/or biomolecule delivery systems;
- to provide them with sufficient background to be able to read and understand the scientific literature in this area; - to foster creative, yet scientifically based, thinking regarding novel approaches or fundamental advances to be made in drug delivery;
- to select, produce and characterize a formulation in terms of morphological, physico-chemical, thermal properties, drug release kinetics, etc.
- gain proficiency in scientific presentation and writing skills in the forms of a written project as well as oral presentations to the entire class.
General characterization
Code
12485
Credits
6.0
Responsible teacher
Ana Isabel Nobre Martins Aguiar de Oliveira Ricardo, Jelena Vladic
Hours
Weekly - 4
Total - 69
Teaching language
Português
Prerequisites
Not applicable
Bibliography
ENGINEERING POLYMER SYSTEMS FOR IMPROVED DRUG DELIVERY, Rebecca A. Bader, David A. Putnam, Eds, 2014, John Wiley & Sons, Inc., Hoboken, New Jersey, USA.
Drug Delivery and Targeting, Anya M.Hillery, Andrew W.Lloyd, James Swarbrick, Eds. 2005, Taylor & Francis Inc, New York, USA.
Teaching method
This course will present the basic material online. In addition, students will attend each week 2h class. These classes will focus on highlighting key or difficult conceptual points, holding discussions and student seminar presentations, and going over example problems for quantitative material. Students will be expected to attend the classes, to study the power points, attempt example problems. Two lab works will complement the theoretical lectures.
This course will be evaluated by the sum of different parts:
- Lectures (30%) - individual work assignments each week (the best 2/3 of the homework assignments will account for your average grade).
- Exploring case studies (40%).
- Practical evaluation – report (5 pages max), presentation and discussion (30%)
A final exam can replace the individual weekly assigments.
Evaluation method
This course will be evaluated by the sum of different parts:
- Lectures (30%) - individual work assignments each week (the best 2/3 of the assignments will account for your average grade).
- Exploring case studies (40%).
- Practical evaluation – report (5 pages max), presentation and discussion (30%)
A final exam can replace the individual weekly assigments.
Subject matter
I – Drug Delivery Systems
1. Fundamentals and challenges of drug delivery.
2. Routes of Drug Delivery.
II – Nanosystems
1. Nanoparticulate.
2. Nanoemulsions
3. Lipossomes.
III – From Nano to Macro
1. Capsules.
2. Aerosols.
3. Dry powder formulations.
4. Oral dispersible films.
5. Membranes
6. Scaffolds
IV - Controlled-Release Delivery Systems
- Chemically controlled devices
- Diffusion controlled, membrane-based and osmotic devices.