Metabolism and Bioenergetics

Objectives

The objectives of this CU are to review and consolidate concepts in the areas of Metabolism and Bioenergetics, focusing on the main metabolic pathways in living cells, how they are regulated and disturbed in disease, and how energy is obtained and transduced to meet a cell’s requirements.

General characterization

Code

11715

Credits

1.5

Responsible teacher

Maria Teresa Nunes Mangas Catarino

Hours

Weekly - Available soon

Total - 25

Teaching language

Português

Prerequisites

There are no prerequisites for attending this curricular unit of the MolBioS doctoral program

Bibliography

1. BIOCHEMISTRY 9^th Ed, Lubert Stryer et al (2019) Bio-Green

(or other Biochemistry textbooks)

2. “Bioenergetics 4”, David G. Nicholls and Stuart J. Ferguson (2013) Academic Press.

3.Metabolism and Disease: Cold Spring Harbor Symposia on Quantitative Biology, Volume LXXVI,

T. Grodzicker, B. Stillman, D. Stewart (Eds), 2012, ISBN 978-1-936113-56-9

4. Selected journal articles

Teaching method

The course will be organized in theoretical and seminars that include discussion of scientific articles and presentation of topics by students.

The lectures will have an interactive format promoting discussion.

In the discussion / presentation sessions of scientific articles, each group of students will choose an article within the themes of the UC. Articles will be critically read by students and presented to colleagues, followed by a discussion period.

In this course there will be continuous assessment that will take into account the student''''s participation in all activities and the quality of your presentations and discussions.

Evaluation method

The evaluation of this CU is continuous and ends with a "chalk presentation" of a scientific article chosen by each group of students.

The presentations asre followed by discussion where everybody is invited to participate.

Students are expected to have a critical view of the articles and are also responsible for steering the debate: criticize, put questions, propose experiments, etc.

Subject matter

1. Review of concepts in Metabolism and Bioenergetics

2. Microbial metabolic diversity

3. The respiratory chain

4. Photosynthesis

5. Diabetes

6. Mitochondrial diseases

7. Biological transport

8. Metabolism and cancer

9. Metabolic models

Programs

Programs where the course is taught: