Molecular Bases of Disease
Objectives
To acquire knowledge and skills about the biochemical mechanisms underlying human disease.
- To understand metabolic processes and associated pathologies.
- To be able to relate biochemical mechanisms with associated pathologies
- To acquire knowledge and skills on a seminar context and to be able to develop critical analysis, using the scientific literature.
- To be able to search and critically interpret the literature.
General characterization
Code
11179
Credits
6.0
Responsible teacher
Paula Alexandra Quintela Videira
Hours
Weekly - 5
Total - 70
Teaching language
Português
Prerequisites
Basic knowledge in Cell and Molecular Biology, Molecular Genetics, Microbiology and Biochemistry.
Bibliography
- Robbins Basic Pathology, 10th Edition, 2018, by Vinay Kumar, MBBS, MD, FRCPath, Abul K. Abbas, MBBS and Jon Aster, MD. ISBN: 9780323353175
-Essential Concepts in Molecular Pathology. (2010) William B. Coleman and Gregory J. Tsongalis (Eds), Academic Press.
-Molecular Basis of Health and Disease (2011) Undurti N. Das, Springer.
Teaching method
The course includes theoretical, and theoretical-practical classes. The lectures will be taught using the "data show", accompanied by complementary bibliography previously available on the website of discipline.
The theoretical-practical classes include seminars focused on specialized subjects, given by invited speakers followed by discussions with active student participation. It also includes as clinical case with questions and discussions in class.
Evaluation method
Two tests on the subjects of lectures - (minimum 10 marks) - each test has a weighting of 35%
Seminar questions - 10%.
Resolution of clinical cases - 15%.
Participation - 5%.
More than 3 absences in the theoretical-practicals - the practical part is not done.
The mark resulting from the theoretical-practicals is kept for 2 years
The absence (non-attendance) in the seminar implies zero grade in that seminar
A delay of more than 20 minutes after the beginning of the seminar will be counted as a lack.
Subject matter
|
Monday 6-3 |
Introduction and presentation of the course Basics of Pathology |
|
13-3 |
Monogenic diseases. Dominant versus recessive diseases. Mutations: types and causes and examples of their pathological effects |
|
|
Cardiovascular and genetic cardiomyopathies |
|
20-3 |
Injury and Cell Death. Apoptosis, necrosis, and cell death pathways |
|
|
Alpha synuclein in Parkinson''''s disease |
|
27-3 |
Infectious diseases- general principles |
|
|
Pathogenesis of Staphylococcus infection |
|
3-4 |
How Microorganisms Cause Disease |
|
|
Clinical case |
|
17-4
|
Inflammation and Repair. Chronic and acute inflammation. |
|
|
Cellular and Molecular Aspects of spondyloarthropaties |
|
24-4 |
Hemodynamic disorders |
|
|
Teste 1 |
|
8-5 |
Diseases of the Immune System |
|
|
Clinical case |
|
15-5 |
Liver function |
|
|
Diabetes |
|
22-5 |
Molecular basis of cancer |
|
|
TBD |
|
29-5 |
Biomarkers of disease and their detection |
|
|
Clinical case |
|
5-6 |
Duvidas |
|
|
|
|
|
|
|
12-6 |
Teste 2 |
Programs
Programs where the course is taught: