Synthetic and Systems Biology A
Objectives
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At the end of this course unit the student will have acquired knowledge, skills and competences that will allow him / her to: - Provide the theoretical basis for modeling biological systems, namely those involving metabolic and regulatory processes; - Identify and describe the methodologies of mathematical representation of cellular processes; - Implement mathematical models of metabolic processes; - List and explain the main analytical methodologies used for the quantification of transcriptome, proteome, fluxoma and metabolome; - List and explain the basic concepts of synthetic biology, including transcriptional regulation and signal transduction circuits; - Identify methods of molecular biology for construction and implementation of synthetic pathways and circuits in cells; - List cutting-edge applications in synthetic biology.
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General characterization
Code
11187
Credits
3.0
Responsible teacher
Ana Sofia Araújo Ferreira, ISABEL CRISTINA DE ALMEIDA PEREIRA DA ROCHA
Hours
Weekly - 1
Total - 42
Teaching language
Português
Prerequisites
Available soon
Bibliography
Markus W. Covert. Fundamentals of Systems Biology: From Synthetic Circuits to Whole-cell Models. CRC Press 2014
Systems Biology: Definitions and Perspectives (Topics in Current Genetics). 2007. Lilia Alberghina, Hans V. Westerhoff (Editors)
Synthetic Biology: Tools for Engineering Biological Systems. Daniel G. Gibson, Clyde A. Hutchison (III), Hamilton Othanel Smith, J. Craig Venter. Cold Spring Harbor Laboratory Press, 2017
Teaching method
The curricular unit includes two types of classes: theoretical and practical. The practical classes will consist mainly of solving practical exercises using different software tools.
Evaluation method
Grades will be awarded based on student participation (15%), assignments and presentations (25%), and a final written exam (60%).
Subject matter
Basic concepts of Systems Biology;
2) Analytical techniques for measuring omic data;
3) Metabolic and transcriptional models;
4) Basic concepts in synthetic biology;
5) Experimental Techniques in Synthetic Biology;
6) Applications of Synthetic Biology.