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Molecular immunology

Objectives

At the end of this course unit the student will have acquired knowledge, skills and competences that allow him / her to:

  Acquire basic knowledge about the mechanisms of the immune response, in the different steps of the immune response.

• Learning the molecular basis and mechanisms of antigen recognition and leukocyte activation

• Identify the role of immune dysfunction in autoimmune diseases and immunodeficiencies.

•Develop skills on the applicability of methodologies / technologies used in the study of Immunology in different areas, such as, basic research, diagnosis and new therapies.

• Apply knowledge in the presentation of the mechanisms of action of immunotherapies

 

General characterization

Code

11188

Credits

3.0

Responsible teacher

Paula Alexandra Quintela Videira

Hours

Weekly - 2

Total - 35

Teaching language

Português

Prerequisites

Available soon

Bibliography

- Immunology: A Short Course, 8th Edition Richard Coico ISBN: 978-1-119-55143-0

https://bcs.wiley.com/he-bcs/Books?action=index&itemId=1119551579&bcsId=11997

- Fundamentos de Imunologia, Lidel - Edições Técnicas,  2ª ediçao, por Fernando A. Arosa, Elsa M. Cardoso e Francisco C. Pacheco

- Janeway’s Immunobiology; Garland Science, by K. Murphy, 10th edition

http://www.ncbi.nlm.nih.gov/books/NBK10757/ 

 

Artigos científicos publicados em revistas internacionais, por ex: Nature Immunology, Nature Reviews Immunology, Journal of Immunology, Molecular Immunology, European Journal of Immunology, 

Teaching method

The teaching comprehends theoretical and theoretical- practical lectures. The theoretical lectures use “data show”, on topics of immunology, complemented with theoretical-practical sessions, including work group of scientific articles and themes. For each class there will exist questions of rapid response, to be discussed in group.

The student will be evaluated according to: 1) a written examination (50% weighting) which will include the themes explored in all classes, 2) presentation of themes (35% weighting); and 3) participation and attitude in class, and discussions of scientific articles (weighting 15%).

Every student enrolled must attend at least 75% of the classes.

The evaluation obtained by attendance of lectures and presentations is valid for two years.

Evaluation method

Assessment methods 

The student will be evaluated according to the weighted average of: 1) a written examination (50% weighting) which will include the themes explored in all classes, 2) presentation of themes (35% weighting); and 3) participation and attitude in class, includes discussions in seminars (weighting 15%). 

Every student enrolled must attend at least 75% of the classes. 

In case of repeated discipline, the evaluation obtained by the attendance of lectures and presentations is valid for two years. 

Subject matter

•          The human immune response in action: general concepts

•          Molecules and mechanisms of innate response

•          Adaptive response and T and B cell cooperation

•          Bases of the diversity of antigen recognition (antibodies and T cell receptors)

•          Th1/Th2 balance

•          Immunologic memory

•          Adhesion molecules and leukocyte migration

•          Cytokines

•          Immune signalling pathways

•          MHC and antigen presentation

•          Immunotherapy

•          Elementary techniques and animal models in Immunology

•          Diagnostic techniques in Immunology

•          Hypersensitivity and autoimmunity

•          Immunodeficiencies