Applied Organic Synthesis
Objectives
This course deals with laboratory techniques in organic chemistry laboratory. This course provides knowledge and experience in an organic chemistry laboratory, which allow students to plan a synthetic route for the preparation of organic compounds. The students must acquire experience in planning an experiment (preparation/purification of reagents and solvents, choice of reaction conditions), monitoring and isolation of the desired compounds. The aim is that student acquire skills of interpretation and critical analysis of the results obtained, planning a chemical reaction and bibliographic search. Upon successful completion of this course students will posess practical skills required for work in modern chemical laboratory.
General characterization
Code
11267
Credits
3.0
Responsible teacher
Luísa Maria da Silva Pinto Ferreira
Hours
Weekly - 2
Total - 28
Teaching language
Inglês
Prerequisites
Available soon
Bibliography
1. J. C. Gilbert, S. F. Martin, “Experimental Organic Chemistry. A Miniscale and Microscale Approach”, Thomson 2006
2. A. I. Vogel, A. R. Tatchell, B. S. Furnis, A. J. Hannaford , P. W. G. Smith “Vogel’s Textbook of practical organic chemistry”,
Prentice Hall 1996
3. J. W. Zubrick “The Organic Chem Lab Survival Manual”, Wiley 2010
4. L. M. Harwood, C. J. Moody, J. M. Percy “Experimental Organic Chemistry, Standard and Microscale”, 2 nd ed., Blackwell Science 1999
5. P. G. M. Wuts, T. W. Greene “Greene’s Protective Groups in Organic Synthesis”, any edition, Wiley & Sons
6. W. L. G. Armarego, C. L. L. Chai, “Purification of Laboratory Chemicals” any edition, Elsevier
7. C. F. Wilcox, Experimental Organic Chemistry, A Small-Scale Approach”, MacMillan Publishing Company, New York 1988
Teaching method
Project-Based Learning – Realistic syntheses, experimental planning, and reaction optimization.
Laboratory Work – Initially guided, then investigative, addressing real challenges.
Computational Tools – Software for molecular design, and spectroscopic analysis.
Reports – Scientific format, critical analysis, and result interpretation.
Continuous Assessment – Experimental execution, safety, autonomy, and problem-solving.
The described methods promote autonomy, critical thinking, and technical proficiency.
Evaluation method
The grade for this course will be determined according to these assessment components:
•25% - written assignments (submitted in moodle)
•35% - experimental laboratory performance
•30% - final report (scientific journal template)
•10% - laboratory journal registration
All experimental sessions are obligatory
Subject matter
The aim is to provide the students with experience with techniques employed in synthetic organic chemistry and to introduce the exciting research area of asymmetric organic synthesis. The program includes a short synthetic sequence, involving different chemical transformations and a final application of the product prepared. This is a research-inspired experiment based on a useful class of chiral catalysts.