Biomaterials, Characterization and Nanofabrication
Objectives
The main objective of this course is to provide students with an in-depth knowledge on structure-composition-processing-properties in biomaterials, from macro- to nano-scale. It is intended that students acquire in-depth knowledge of biomaterial characterization techniques from the macro- to the nano-scale and in the manufacturing processes of (bio)nanomaterials. Lab projects will be offered to students to obtain hands-on experience on bio(nano)materials processing and characterization.
General characterization
Code
13323
Credits
6.0
Responsible teacher
Ana Catarina Bernardino Baptista, João Paulo Miranda Ribeiro Borges
Hours
Weekly - 4
Total - 56
Teaching language
Português
Prerequisites
Available soon
Bibliography
1. Buddy D. Ratner et. al (ed), Biomaterials Science - An introduction to Materials in Medicine, Academic Press, New York, (4th Ed.), 2020.
2. Z. Cui, Nanofabrication: Principles, Capabilities and Limits, Springer (2nd edition), 2017.
3. S. Thomas, R. Thomas, A. Zachariah, R. Kumar, Spectroscopic Methods for Nanomaterials Characterization, Volume 2, Elsevier (1st edition), 2017
4. S.K. Sharma, (Ed), Handbook of Materials Characterization, Springer (1st edition), 2018
5. Chu, P.K., Liu, X., (Eds.), Biomaterials Fabrication and Processing Handbook, CRC Press, 2008.
Teaching method
The lectures will be supported by powerpoint slides.
The practical classes will be conducted in the laboratory, where students perform exploratory experimental activities of the topics covered in the lectures.
Evaluation method
The evaluation will consist of a theoretical-practical component (60%) and a practical component (40%).
- The evaluation of the theoretical-practical component (TP) will consider the following elements:
- 2 tests (individual) - 45%
- 1 case study presentation (Group) - 15%
- The evaluation of the practical component will consider the following elements:
- 4 questionnaires - 10% each
Subject matter
TP
1. Introduction to materials for medical applications
2. Synthetic (biodegradable or non-biodegradable) and Natural Biomaterials
a. Structure-Composition-Processing-Properties Relationships
b. Selection of biomaterials for medical applications
3. Characterization Part I: Techniques Using Ionizing Radiation Excitation (XPS, AES, RBS, SIMS, XRD)
4. Characterization Part II: Microscopy Techniques (Confocal, SEM, (S)TEM, and AFM)
5. Characterization Part III: Spectroscopy Techniques (Raman, Ellipsometry, FTIR, UV-VIS-NIR)
6. Introduction to Nanofabrication and Nanocaracterization
7. Nanofabrication Using Bottom-Up Techniques: Growth of Nanostructures via Self-Assembly and Guided Self-Assembly, Atomic Layer Deposition, Vapor-Growth and Solution Processes, Alignment of Nanostructures
8. Nanofabrication Using Top-Down Techniques: Overview of Optical, Electron, and Ion Beam Lithography. Nanofabrication by Replication. Material Modification via Laser-Induced Techniques: The Example of Laser-Induced Graphene (LIG).
PL
- Synthesis and Characterization of Mesoporous Bioactive Glass
- Adsorption of a Protein onto the Surface of a Titanium Substrate
- Preparation of Microparticles for Medical Applications
- Preparation of Bioinks and Bioprinting Technologies for Biomedical Applications