Molecular Bases of Disease
Objectives
To acquire knowledge and skills about the biochemical mechanisms underlying human disease.
- To understand metabolic processes and associated pathologies.
- To be able to relate biochemical mechanisms with associated pathologies
- To acquire knowledge and skills on a seminar context and to be able to develop critical analysis, using the scientific literature.
- To be able to search and critically interpret the literature.
General characterization
Code
11179
Credits
6.0
Responsible teacher
Paula Alexandra Quintela Videira
Hours
Weekly - 5
Total - 70
Teaching language
Português
Prerequisites
Basic knowledge in Cell and Molecular Biology, Molecular Genetics, Microbiology and Biochemistry.
Bibliography
- Robbins and Kumar''s Basic Pathology, (2022) 11th Edition, Vinay Kumar (ALICE HOGGE AND ARTH) Editor Elsevier - health sciences division EAN 9780323790185 ISBN 9780323790185 -Molecular Basis of Health and Disease (2011) Undurti N. Das, Springer.
Teaching method
The course includes theoretical, and theoretical-practical classes. The lectures will be taught using the "data show", accompanied by complementary bibliography previously available on the website of discipline.
The theoretical-practical classes include seminars focused on specialized subjects, given by invited speakers followed by discussions with active student participation. It also includes as clinical case with questions and discussions in class.
Evaluation method
Two tests on the subjects of lectures - (minimum 10 marks) - each test has a weighting of 35%
Seminar questions - 10%.
Resolution of clinical cases - 15%.
Participation - 5%.
More than 3 absences in the theoretical-practicals - the practical part is not done.
The mark resulting from the theoretical-practicals is kept for 2 years
The absence (non-attendance) in the seminar implies zero grade in that seminar
A delay of more than 20 minutes after the beginning of the seminar will be counted as a lack.
Subject matter
|
Monday 10-3 |
Introduction and presentation of the course Basics of Pathology Introduction to biomarkers of disease and their detection |
Paula Videira
|
|
17-3 |
Injury and Cell Death. Apoptosis, necrosis, and cell death pathways |
Margarida Braga |
|
|
Lysosomal dysfunction in age-related macular degeneration |
Ana Sofia Falcão, NOVA-NMS |
|
24-3 |
Genetic related diseases |
Paula Videira |
|
|
GNE myopathy: A case study in monogenic rare disease
|
Mariana Barbosa, NOVA FCT |
|
31-3 |
Inflammation and Repair. Chronic and acute inflammation. |
Paula Videira |
|
|
From -omics Technologies to clinical practice
|
Fernando Pimentel, NOVA-NMS |
|
7-4 |
How Microorganisms Cause Disease |
Irina Franco, NOVA FCT |
|
|
Legionella pneumophila: virulence factors and modulation of host cell pathways |
Irina Franco, NOVA FCT |
|
14-4
|
Diseases of Embryonic Development |
Renata
|
|
|
Explanation of Clinical cases
|
Renata |
|
28-4 |
Hemodynamic Disorders, Thromboembolism, and Shock |
Paula Videira |
|
28-4 |
Teste 1 |
|
|
5-5 |
Diseases of the Immune System |
Paula Videira |
|
|
Extracellular Vesicles: Deciphering their Role in Obesity and Diabetes Pathophysiology |
Rita Oliveira, NOVA-NMS |
|
12-5 |
Liver and gallbladder function |
Paula Videira |
|
|
Mentoring |
|
|
19-5 |
Molecular basis of cancer |
Renata Freitas |
|
|
Clinical case |
|
|
26-5 |
Diseases of the reproductive tract |
Renata Freitas |
|
|
Clinical case |
|
|
2-6 |
Ageing |
Renata Freitas |
|
|
Clinical case |
|
|
9 - 6 |
Teste 2 |
|
Programs
Programs where the course is taught: