Immunology
Objectives
- Acquisition of knowledge about the constitution and function of the Immune System and the mechanisms of immune response, in the different steps of the immune response.
- Learning of basic principles that relate to cells and molecules of the immune system in the defense against pathogens and how they are developed to recognize antigens.
- Acquisition of knowledge on the role of immune dysfunction in autoimmune diseases and immunodeficiencies.
- Development of skills on the applicability of methodologies / technologies used in the study of Immunology in different areas, such as, basic research and diagnosis.
- Understanding the dynamics of knowledge contained in a rapidly developing science that integrates in all other biomedical sciences.
General characterization
Code
10656
Credits
6.0
Responsible teacher
Paula Alexandra Quintela Videira
Hours
Weekly - 4
Total - 74
Teaching language
Português
Prerequisites
Basic knowledge in Cell and Molecular Biology, Molecular Genetics, Microbiology and Biochemistry
Bibliography
- Janeway’s Immunobiology; nineth edition, Garland Science, by Kenneth Murphy and Casey Weaver
- Fundamentos de Imunologia, Lidel - Edições Técnicas, 2ª ediçao, por Fernando A. Arosa, Elsa M. Cardoso e Francisco C. Pacheco
- Cellular and Molecular Immunology, Saunders/Elsevier, 2011 by Abbas, Lichtman, and Pillai
- Kuby Immunology; Kindt, Goldsby, Osborne
Teaching method
The teaching of this curricular unit has a mainly theoretical and practical character that will allow the students to acquire and apply the knowledge in the Immunology area. The theoretical lessons are expository with a component of continuous participation of students. The practical classes apply sequentially concepts acquired in theoretical classes in laboratory practice, stimulating the ability of students to apply and report the knowledge acquired. It is intended to engage the student from the beginning to the study of Immunology, encouraging discussion and criticism, cementing the knowledge, allowing interrelationship between the various topics themselves and even with other areas of biological sciences and creating the basis for possible application of immunology in their future work.
The language of instruction is Portuguese, and the slides will be in English.
In the event of having foreign students, there may be some teaching moments in English.
Evaluation method
The assessment of this unit is continuous. The assessment components are:
(A) theoretical assessment;
i) Consisting of mini-tests. Each mini-test has a weight of 25% each (total value of mini-tests = 50%) and include theoretical matters and each has a maximum duration of 60 minutes.
(B) laboratory or project assessment;
i) – Seminar /group work: weight of 25%. The themes, content and organization will be defined in the first two weeks of classes. The classification of work entails the presentation in the form of seminar and discussion.
ii) - Report: weight of 20%. Report and discussion of experiments.
iii) - Resolution of questions during the practical lectures: weight of 5%
(C) summative assessment;
ii) - Participation and attendance in class:
Classification attributed to final grade:
A Good - rises 1 point to note
B Enough -gets 0 points to note
C Bad- decreases 1 value
Rating
Ai*50% + Bi*25% + Bii*20% + Biii*5%
Only the final grade is rounded !
40% of the evaluation will be held until the eighth week of the semester.
The minimum required for each component rating is 8/20.
All enrolled students must attend at least 2/3 of practical classes.
In the case of grade improvement in the exam, the grades of elements such as group work, individual work and participation during the class may remain.
In case of repetition of the discipline, the frequency of theoretical and practices lectures is valid for two years. During these two years, the student can choose to keep the score obtained prior to any of the assessment components, provided that the grades for that component were higher than 10. However, the student must always validate the grade given through a small practical test (to match the conductor), to ensure their notes.
Subject matter
DATA |
TÍTULO |
16/09 |
Apresentação/ Aspectos gerais da Imunologia |
23/09 |
Resposta inata |
30/09 |
Antigénios e anticorpos |
7/10 |
Resposta imune mediada por células T e B |
14/10 |
Fases da resposta imunitária |
21/10 |
Citocinas / Imunoterapia (I) |
28/10 |
Organização e expressão dos genes das Imunoglobulinas e recetores de células T |
4/11 |
Complexo Major de Histocompatibilidade. |
11/11 |
Imunohematologia |
18/11 |
Imunologia tumoral / Imunoterapia (II) |
25/11 |
Imunodeficiencia, Hipersensibilidade e Autoimunidade |
2/12 |
Vacinas/ Processos de produção de vacinas |
|
|
|
|
1º teste-22 Outubro
2º teste-16 Dezembro
CALENDÁRIO DAS AULAS PRÁTICAS
Semana |
Dia da Aula teórica |
Aula pratica (P1 e P2) |
|
Semana 1 |
16/09 |
Introdução – células sanguíneas |
Paula Videira |
Semana 2 |
23/09 |
Cultura de células |
Zélia Silva |
Semana 3 |
30/09 |
Isolamento de leucócitos |
Zelia Silva |
Semana 4 |
7/10 |
Estimulação |
Zelia Silva |
Semana 5 |
14/10 |
Citometria de fluxo e fagocitose |
Zelia Silva |
Semana 6 |
21/10 |
ELISA |
Zelia Silva |
Semana 7 |
28/10 |
|
|
Semana 8 |
4/11 |
Imunização e Tecnologia de anticorpos monoclonais |
Paula Videira |
Semana 9 |
11/11 |
Imunohematologia |
Paula Videira |
Semana 10 |
18/11 |
SEMINÁRIOS dos alunos (4 Grupos) |
Paula Videira, Zelia Silva |
Semana 11 |
25/11 |
SEMINÁRIOS dos alunos (4 grupos) |
Paula Videira, Zelia Silva |
Semana 12 |
2/12 |
Duvidas |
Paula Videira |