Immunology

Objectives

- Acquisition of knowledge about the constitution and function of the Immune System and the mechanisms of immune response, in the different steps of the immune response.

- Learning of basic principles that relate to cells and molecules of the immune system in the defense against pathogens and how they are developed to recognize antigens.

- Acquisition of knowledge on the role of immune dysfunction in autoimmune diseases and immunodeficiencies.

- Development of skills on the applicability of methodologies / technologies used in the study of Immunology in different areas, such as, basic research and diagnosis.

- Understanding the dynamics of knowledge contained in a rapidly developing science that integrates in all other biomedical sciences.

General characterization

Code

10656

Credits

6.0

Responsible teacher

Paula Alexandra Quintela Videira

Hours

Weekly - 4

Total - 74

Teaching language

Português

Prerequisites

Basic knowledge in Cell and Molecular Biology, Molecular Genetics, Microbiology and Biochemistry

Bibliography

- Janeway’s Immunobiology; nineth edition, Garland Science, by Kenneth Murphy and Casey Weaver

- Fundamentos de Imunologia, Lidel - Edições Técnicas,  2ª ediçao, por Fernando A. Arosa, Elsa M. Cardoso e Francisco C. Pacheco 

- Cellular and Molecular Immunology, Saunders/Elsevier, 2011 by Abbas, Lichtman, and Pillai

- Kuby Immunology; Kindt, Goldsby, Osborne

Teaching method

The teaching of this curricular unit has a mainly theoretical and practical character that will allow the students to acquire and apply the knowledge in the Immunology area. The theoretical lessons are expository with a component of continuous participation of students. The practical classes apply sequentially concepts acquired in theoretical classes in laboratory practice, stimulating the ability of students to apply and report the knowledge acquired. It is intended to engage the student from the beginning to the study of Immunology, encouraging discussion and criticism, cementing the knowledge, allowing interrelationship between the various topics themselves and even with other areas of biological sciences and creating the basis for possible application of immunology in their future work.
The language of instruction is Portuguese, and the slides will be in English.
In the event of having foreign students, there may be some teaching moments in English.

Evaluation method

The assessment of this unit is continuous. The assessment components are:

(A) theoretical assessment;

i) Consisting of mini-tests. Each mini-test has a weight of 25% each (total value of mini-tests = 50%) and include theoretical matters and each has a maximum duration of 60 minutes.

 

(B) laboratory or project assessment;

i) – Seminar /group work: weight of 25%. The themes, content and organization will be defined in the first two weeks of classes. The classification of work entails the presentation in the form of seminar and discussion.

ii) - Report: weight of 20%. Report and discussion of experiments.

iii) - Resolution of questions during the practical lectures: weight of 5%

 

(C) summative assessment;

ii) - Participation and attendance in class:

Classification attributed to final grade:

A Good - rises 1 point to note

B Enough -gets 0 points to note

C Bad-  decreases 1 value

 

Rating

Ai*50% + Bi*25% + Bii*20% + Biii*5%

Only the final grade is rounded !

 

40% of the evaluation will be held until the eighth week of the semester.

The minimum required for each component rating is 8/20.

All enrolled students must attend at least 2/3 of practical classes.

In the case of grade improvement in the exam, the grades of elements such as group work, individual work and participation during the class may remain.

In case of repetition of the discipline, the frequency of theoretical and practices lectures is valid for two years. During these two years, the student can choose to keep the score obtained prior to any of the assessment components, provided that the grades for that component were higher than 10. However, the student must always validate the grade given through a small practical test (to match the conductor), to ensure their notes.

 

Subject matter

DATA

TÍTULO

16/09

Apresentação/ Aspectos gerais da Imunologia

23/09

Resposta inata

30/09

Antigénios e anticorpos

7/10

Resposta imune mediada por células T e B

14/10

Fases da resposta imunitária

21/10

Citocinas / Imunoterapia (I)

28/10

Organização e expressão dos genes das Imunoglobulinas e recetores de células T

4/11

Complexo Major de Histocompatibilidade.

11/11

Imunohematologia

18/11

Imunologia tumoral / Imunoterapia (II)

25/11

Imunodeficiencia, Hipersensibilidade e Autoimunidade

2/12

Vacinas/ Processos de produção de vacinas

 

 

 

 

1º teste-22 Outubro

2º teste-16 Dezembro

 

 

 

 

CALENDÁRIO DAS AULAS PRÁTICAS

  

Semana

Dia da Aula teórica

Aula pratica (P1 e P2)

 

Semana 1

16/09

Introdução – células sanguíneas

Paula Videira

Semana 2

23/09

Cultura de células

Zélia Silva

Semana 3

30/09

Isolamento de leucócitos

Zelia Silva

Semana 4

7/10

Estimulação 

Zelia Silva

Semana 5

14/10

Citometria de fluxo e fagocitose

Zelia Silva

Semana 6

21/10

ELISA

Zelia Silva

Semana 7

28/10

 

 

Semana 8

4/11

Imunização e Tecnologia de anticorpos monoclonais

Paula Videira

Semana 9

11/11

Imunohematologia

Paula Videira

Semana 10

18/11

SEMINÁRIOS dos alunos (4 Grupos)

Paula Videira, Zelia Silva

Semana 11

25/11

SEMINÁRIOS dos alunos (4 grupos)

Paula Videira, Zelia Silva

Semana 12

2/12

Duvidas

Paula Videira

 

Programs

Programs where the course is taught: